CDC7

All methods over the ±5 window, side by side.

PSPA

CDDM

MLP-attr

Normalized values from positional scanning peptide array

PSPA measures pT, so at flanking positions the pS row is a duplicate of the pT row. At position 0 the acceptor identity (pS, pT, pY) is genuine.

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Position-wise Probabilities (±5 window)

Log-Odds (±5 window)

Motifs stratified by phospho-acceptor (S / T / Y)

K-means sub-motif clusters

Signed attribution PSSM distilled from the CDDM discriminative MLP (in-silico saturation mutagenesis). Letters above 0 are enriched, below are depleted; this is not a probability distribution.

MLP-attribution PSSM (±5, signed)

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substrate_uniprot	site	source	substrate_genes	site_seq
O00311	S216	EPSD\|PSP	CDC7 CDC7L1	DFGLAQGTHDTKIELLKFVQsEAQQERCSQNKSHIITGNKI
O00311	S239	EPSD\|PSP	CDC7 CDC7L1	QQERCSQNKSHIITGNKIPLsGPVPKELDQQSTTKASVKRP
O00311	S277	EPSD\|PSP	CDC7 CDC7L1	KRPYTNAQIQIKQGKDGKEGsVGLsVQRsVFGERNFNIHss
O00311	S285	EPSD\|PSP	CDC7 CDC7L1	IQIKQGKDGKEGsVGLsVQRsVFGERNFNIHssISHEsPAV
O00311	S296	EPSD\|PSP	CDC7 CDC7L1	GsVGLsVQRsVFGERNFNIHssISHEsPAVKLMKQSKTVDV
O00311	S297	EPSD\|PSP	CDC7 CDC7L1	sVGLsVQRsVFGERNFNIHssISHEsPAVKLMKQSKTVDVL
O00311	S318	EPSD\|PSP	CDC7 CDC7L1	ISHEsPAVKLMKQSKTVDVLsRKLATKKKAISTKVMNSAVM
O75475	S206	SIGNOR\|EPSD\|PSP	PSIP1 DFS70 LEDGF PSIP2	TEVKIPKPRGRPKMVKQPCPsEsDIItEEDKSKKKGQEEKQ
P06748	S137	EPSD\|PSP	NPM1 NPM	VAVEEDAEsEDEEEEDVKLLsIsGKRsAPGGGsKVPQKKVK
P06748	T199	EPSD\|PSP	NPM1 NPM	DDFDDEEAEEKAPVKKsIRDtPAKNAQKSNQNGKDsKPsst
P11388	S1213	EPSD\|PSP	TOP2A TOP2	LPGKGGKAKGKKTQMAEVLPsPRGQRVIPRITIEMKAEAEK
P11388	S1525	EPSD\|PSP	TOP2A TOP2	AVAPRAKSVRAKKPIKYLEEsDEDDLF______________
P19338	T121	EPSD\|PSP	NCL	AKAVTtPGKKGAtPGKALVAtPGKKGAAIPAKGAKNGKNAK
P19338	T76	EPSD\|PSP	NCL	AAATsAKKVVVsPtKKVAVAtPAKKAAVtPGKKAAAtPAKK
P49736	S108	GPS6\|SIGNOR\|EPSD\|PSP	MCM2 BM28 CCNL1 CDCL1 KIAA0030	DAYEAEGLALDDEDVEELtAsQREAAERAMRQRDREAGRGL
P49736	S13	SIGNOR	MCM2 BM28 CCNL1 CDCL1 KIAA0030	________MAEssEsFtMAssPAQRRRGNDPLtssPGRssR
P49736	S139	SIGNOR\|EPSD\|PSP	MCM2 BM28 CCNL1 CDCL1 KIAA0030	QRDREAGRGLGRMRRGLLyDsDEEDEERPARKRRQVERAtE
P49736	S220	EPSD\|PSP	MCM2 BM28 CCNL1 CDCL1 KIAA0030	KNFLRTHVDsHGHNVFKERIsDMCKENREsLVVNyEDLAAR
P49736	S27	SIGNOR\|EPSD\|PSP	MCM2 BM28 CCNL1 CDCL1 KIAA0030	sFtMAssPAQRRRGNDPLtssPGRssRRtDALtssPGRDLP
P49736	S31	EPSD\|PSP	MCM2 BM28 CCNL1 CDCL1 KIAA0030	AssPAQRRRGNDPLtssPGRssRRtDALtssPGRDLPPFED
P49736	S4	EPSD\|PSP	MCM2 BM28 CCNL1 CDCL1 KIAA0030	_________________MAEssEsFtMAssPAQRRRGNDPL
P49736	S40	GPS6\|SIGNOR\|EPSD\|PSP	MCM2 BM28 CCNL1 CDCL1 KIAA0030	GNDPLtssPGRssRRtDALtssPGRDLPPFEDEsEGLLGtE
P49736	S41	SIGNOR\|EPSD\|PSP	MCM2 BM28 CCNL1 CDCL1 KIAA0030	NDPLtssPGRssRRtDALtssPGRDLPPFEDEsEGLLGtEG
P49736	S5	SIGNOR\|EPSD\|PSP	MCM2 BM28 CCNL1 CDCL1 KIAA0030	________________MAEssEsFtMAssPAQRRRGNDPLt
P49736	S53	GPS6\|SIGNOR\|EPSD\|PSP	MCM2 BM28 CCNL1 CDCL1 KIAA0030	RRtDALtssPGRDLPPFEDEsEGLLGtEGPLEEEEDGEELI
P49736	S7	EPSD\|PSP	MCM2 BM28 CCNL1 CDCL1 KIAA0030	______________MAEssEsFtMAssPAQRRRGNDPLtss
P55081	S116	EPSD\|PSP	MFAP1	DVEERLARHRKIVEPEVVGEsDsEVEGDAWRMEREDssEEE
Q8TEA8	S179	SIGNOR\|PSP	DTD1 C20orf88 DUEB HARS2	QLSKLEKQQQRKEKTRAKGPsEssKERNtPRKEDRsAssGA
Q8TEA8	S181	SIGNOR\|PSP	DTD1 C20orf88 DUEB HARS2	SKLEKQQQRKEKTRAKGPsEssKERNtPRKEDRsAssGAEG
Q8TEA8	S182	SIGNOR\|PSP	DTD1 C20orf88 DUEB HARS2	KLEKQQQRKEKTRAKGPsEssKERNtPRKEDRsAssGAEGD
Q8TEA8	S194	SIGNOR\|PSP	DTD1 C20orf88 DUEB HARS2	RAKGPsEssKERNtPRKEDRsAssGAEGDVssEREP_____
Q8TEA8	S196	SIGNOR\|PSP	DTD1 C20orf88 DUEB HARS2	KGPsEssKERNtPRKEDRsAssGAEGDVssEREP_______
Q8TEA8	S197	SIGNOR\|PSP	DTD1 C20orf88 DUEB HARS2	GPsEssKERNtPRKEDRsAssGAEGDVssEREP________
Q8TEA8	S204	SIGNOR\|PSP	DTD1 C20orf88 DUEB HARS2	ERNtPRKEDRsAssGAEGDVssEREP_______________
Q8TEA8	S205	SIGNOR\|PSP	DTD1 C20orf88 DUEB HARS2	RNtPRKEDRsAssGAEGDVssEREP________________
Q8TEA8	T187	SIGNOR\|PSP	DTD1 C20orf88 DUEB HARS2	QQRKEKTRAKGPsEssKERNtPRKEDRsAssGAEGDVssER
Q96GD4	T236	PSP	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	IADFGWSVHAPsLRRKtMCGtLDYLPPEMIEGRMHNEKVDL
Q9HAW4	S110	EPSD\|PSP	CLSPN	ENLYAGKNTKIKRIYKTVADsDESYMEKSLyQENLEAQVKP
Q9HAW4	S1129	EPSD\|PSP	CLSPN	DDKRQLRLYQERYLADGDLHsDGPGRMRKFRWKNIDDAsQM
Q9HAW4	S1147	EPSD\|PSP	CLSPN	LHsDGPGRMRKFRWKNIDDAsQMDLFHRDsDDDQtEEQLDE
Q9HAW4	S260	EPSD\|PSP	CLSPN	VKNKVKKHKKKEPSLESGVHsFEEGsELSKGTTRKERKAAR
Q9HAW4	S265	EPSD\|PSP	CLSPN	KKHKKKEPSLESGVHsFEEGsELSKGTTRKERKAARLSKEA
Q9HAW4	S67	EPSD\|PSP	CLSPN	DEEIFVSKKLKNRKVLQDsDsEtEDTNAsPEKttyDsAEEE
Q9HAW4	S704	EPSD\|PSP	CLSPN	SEEIETKDEKEMDKENNDGssEIGKAVGFLSVPKSLssDst
Q9HAW4	S721	EPSD\|PSP	CLSPN	DGssEIGKAVGFLSVPKSLssDstLLLFKDSSSKMGYFPTE
Q9HAW4	S744	EPSD\|PSP	CLSPN	tLLLFKDSSSKMGYFPTEEKsETDENSGKQPSKLDEDDsCs
Q9NS91	S434	SIGNOR\|EPSD\|PSP	RAD18 RNF73	EPDREEDSSSCIDIQEVLSSsESDSCNSSSSDIIRDLLEEE
Q9UBU7	S312	EPSD\|PSP	DBF4 ASK DBF4A ZDBF1	KKGYCECCLQKYEDLEtHLLsEQHRNFAQSNQYQVVDDIVS
Q9UBU7	T273	EPSD\|PSP	DBF4 ASK DBF4A ZDBF1	FDVDKPssMQKQTQVKLRIQtDGDKYGGtsIQLQLKEKKKK
Q9UBU7	T281	EPSD\|PSP	DBF4 ASK DBF4A ZDBF1	MQKQTQVKLRIQtDGDKYGGtsIQLQLKEKKKKGYCECCLQ