DYRK1B

All methods over the ±5 window, side by side.

PSPA

CDDM

MLP-attr

Normalized values from positional scanning peptide array

PSPA measures pT, so at flanking positions the pS row is a duplicate of the pT row. At position 0 the acceptor identity (pS, pT, pY) is genuine.

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Position-wise Probabilities (±5 window)

Log-Odds (±5 window)

Motifs stratified by phospho-acceptor (S / T / Y)

K-means sub-motif clusters

Signed attribution PSSM distilled from the CDDM discriminative MLP (in-silico saturation mutagenesis). Letters above 0 are enriched, below are depleted; this is not a probability distribution.

MLP-attribution PSSM (±5, signed)

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substrate_uniprot	site	source	substrate_genes	site_seq
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75533	T434	GPS6\|ELM\|iPTMNet\|EPSD\|PSP	SF3B1 SAP155	VLPPPAGYVPIRtPARKLtAtPtPLGGMtGFHMQTEDRTMK
O95817	S173	Sugiyama	BAG3 BIS	QVAAAAAAQPPAsHGPERsQsPAAsDCsssSsSAsLPssGR
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P07814	T737	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	EKTKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRV
P08195	S607	Sugiyama	SLC3A2 MDU1	ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P11142	T37	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P13807	S641	SIGNOR	GYS1 GYS	FTYEPNEADAAQGyRyPRPAsVPPsPsLsRHssPHQsEDEE
P15559	S82	Sugiyama	NQO1 DIA4 NMOR1	DPANFQYPAESVLAYKEGHLsPDIVAEQKKLEAADLVIFQF
P18754	S11	Sugiyama	RCC1 CHC1	__________MsPKRIAKRRsPPADAIPKsKKVKVsHRsHs
P20823	S249	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	HNF1A TCF1	RETLVEECNRAECIQRGVsPsQAQGLGSNLVTEVRVYNWFA
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P24385	T288	SIGNOR\|EPSD\|PSP	CCND1 BCL1 PRAD1	PKAAEEEEEEEEEVDLACtPtDVRDVDI_____________
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P28066	S16	Sugiyama	PSMA5	_____MFLTRsEyDRGVNtFsPEGRLFQVEyAIEAIKLGST
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34931	T39	Sugiyama	HSPA1L	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837	S13	Sugiyama	TALDO1 TAL TALDO TALDOR	________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646	T86	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P38936	S153	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1	GPGDSQGRKRRQtsMTDFYHsKRRLIFSKRKP_________
P39019	Y48	Sugiyama	RPS19	LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P42166	S159	Sugiyama	TMPO LAP2	RKLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsND
P42167	S159	Sugiyama	TMPO LAP2	RKLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSND
P46527	S10	SIGNOR	CDKN1B KIP1 p27	___________MSNVRVSNGsPsLERMDARQAEHPKPSACR
P47712	S724	Sugiyama	PLA2G4A CPLA2 PLA2G4	NIDVIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFL
P47712	S727	Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P51991	Y360	Sugiyama	HNRNPA3 HNRPA3	QSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsRRF__
P54652	T38	Sugiyama	HSPA2	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P55884	S117	Sugiyama	EIF3B EIF3S9	AEPPVPAQGEAPGEQARDERsDsRAQAVsEDAGGNEGRAAE
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263	T107	Sugiyama	RPS14 PRO2640	ELGITALHIKLRATGGNRtKtPGPGAQsALRALARSGMKIG
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62917	S14	Sugiyama	RPL8	_______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P68363	Y432	Sugiyama	TUBA1B	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P84243	T46	EPSD	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	ARKsAPsTGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q02363	T27	EPSD\|PSP	ID2 BHLHB26	VRSVRKNsLSDHSLGISRsKtPVDDPMSLLYNMNDCYSKLK
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q07960	S51	Sugiyama	ARHGAP1 CDC42GAP RHOGAP1	KNWPsDEMPDFPKsDDsKsssPELVtHLKWDDPyyDIARHQ
Q13247	S301	Sugiyama	SRSF6 SFRS6 SRP55	PKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKR
Q13247	S303	Sugiyama	SRSF6 SFRS6 SRP55	ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13627	S97	Sugiyama	DYRK1A DYRK MNB MNBH	LQRRMPQtFRDPAtAPLRKLsVDLIKTYKHINEVyYAKKKR
Q13627	Y111	Sugiyama	DYRK1A DYRK MNB MNBH	APLRKLsVDLIKTYKHINEVyYAKKKRRHQQGQGDDSSHKK
Q13627	Y321	Sugiyama	DYRK1A DYRK MNB MNBH	SAIKIVDFGSSCQLGQRIyQyIQSRFYRSPEVLLGMPYDLA
Q14160	S1486	Sugiyama	SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL	RHQERLRVQsPEPPAPERALsPAELRALEAEKRALWRAARM
Q14258	S100	Sugiyama	TRIM25 EFP RNF147 ZNF147	DLAREPPADVWtPPARAsAPsPNAQVACDHCLKEAAVKTCL
Q52LA3	S28	PSP	LIN52 C14orf46	PTDGTDLEASLLSFEKLDRAsPDLWPEQLPGVAEFAAsFKs
Q71U36	Y432	Sugiyama	TUBA1A TUBA3	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q86W56	Y832	Sugiyama	PARG	DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q8IZ21	S118	Sugiyama	PHACTR4 PRO2963	PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8TC07	S675	Sugiyama	TBC1D15	TSAFQSNALPTLSASGARNDsPtQIPVssDVCRLtPA____
Q8WWM7	S111	Sugiyama	ATXN2L A2D A2LG A2LP A2RP	PGAAAIGsARGQstGKGPPQsPVFEGVyNNSRMLHFLTAVV
Q96KQ7	T555	PSP	EHMT2 BAT8 C6orf30 G9A KMT1C NG36	HCGEDASEAQEVTIPRGDGVtPPAGtAAPAPPPLsQDVPGR
Q99801	S185	PSP	NKX3-1 NKX3.1 NKX3A	EtQVKIWFQNRRYKTKRKQLssELGDLEKHssLPALKEEAF
Q99801	S186	PSP	NKX3-1 NKX3.1 NKX3A	tQVKIWFQNRRYKTKRKQLssELGDLEKHssLPALKEEAFS
Q9C0C2	S1103	Sugiyama	TNKS1BP1 KIAA1741 TAB182	KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2	S672	Sugiyama	TNKS1BP1 KIAA1741 TAB182	TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9HCN4	S301	Sugiyama	GPN1 MBDIN RPAP4 XAB1 HUSSY-23	ANAESQQQREQLERLRKDMGsVALDAGtAKDsLsPVLHPsD
Q9NTJ3	T48	Sugiyama	SMC4 CAPC SMC4L1	sDAEPEPPsGRtEsPAtAAEtAsEELDNRSLEEILNSIPPP
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKV0	S240	SIGNOR	HDAC9 HDAC7 HDAC7B HDRP KIAA0744 MITR	sEPNLKVRSRLKQKVAERRssPLLRRKDGNVVTsFKKRMFE
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S295	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRSRSRSAAAKtHttALAGRsPsPAsGRRGEGDAPFsEPGt
Q9UQ35	S297	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRSRSAAAKtHttALAGRsPsPAsGRRGEGDAPFsEPGtts
Q9UQL6	S279	SIGNOR	HDAC5 KIAA0600	sEPNLKVRSRLKQKVAERRssPLLRRKDGTVIStFKKRAVE
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y463	S421	EPSD\|PSP	DYRK1B MIRK	YLRFQDLVLRMLEYEPAARIsPLGALQHGFFRRTADEATNT
Q9Y463	S49	Sugiyama	DYRK1B MIRK	LPRRLPLAFRDATSAPLRKLsVDLIKTYKHINEVyYAKKKR
Q9Y463	Y271	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	DYRK1B MIRK	KRSAIKIVDFGSSCQLGQRIyQyIQSRFYRSPEVLLGTPYD
Q9Y463	Y273	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP\|Sugiyama	DYRK1B MIRK	SAIKIVDFGSSCQLGQRIyQyIQSRFYRSPEVLLGTPYDLA
Q9Y463	Y63	Sugiyama	DYRK1B MIRK	APLRKLsVDLIKTYKHINEVyYAKKKRRAQQAPPQDSSNKK