MAP2K3

All methods over the ±5 window, side by side.

CDDM

MLP-attr

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Position-wise Probabilities (±5 window)

Log-Odds (±5 window)

Motifs stratified by phospho-acceptor (S / T / Y)

K-means sub-motif clusters

Signed attribution PSSM distilled from the CDDM discriminative MLP (in-silico saturation mutagenesis). Letters above 0 are enriched, below are depleted; this is not a probability distribution.

MLP-attribution PSSM (±5, signed)

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substrate_uniprot	site	source	substrate_genes	site_seq
O00165	S153	Sugiyama	HAX1 HS1BP1	PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O14545	T323	Sugiyama	TRAFD1 FLN29	ELLIDHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQ
O15264	T180	GPS6\|SIGNOR\|EPSD\|PSP	MAPK13 PRKM13 SAPK4	EDCELKILDFGLARHADAEMtGyVVtRWYRAPEVILSWMHY
O15264	Y182	SIGNOR\|EPSD\|PSP	MAPK13 PRKM13 SAPK4	CELKILDFGLARHADAEMtGyVVtRWYRAPEVILSWMHYNQ
O60361	Y136	Sugiyama	NME2P1	SLRFKPEELVDYKSCAHDWVyE___________________
O60664	Y95	Sugiyama	PLIN3 M6PRBP1 TIP47	VsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQPTE
P00338	Y239	Sugiyama	LDHA PIG19	GtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVADL
P00558	S415	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	GGGAsLELLEGKVLPGVDALsNI__________________
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733	T41	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG
P06733	Y44	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07195	S320	Sugiyama	LDHB	GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07237	Y94	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07900	S53	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900	Y284	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238	Y276	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238	Y301	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P09104	Y44	Sugiyama	ENO2	LyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKGVLK
P11142	Y41	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P13929	Y44	Sugiyama	ENO3	LHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKGVLK
P17066	Y43	Sugiyama	HSPA6 HSP70B'	FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P17812	S575	Sugiyama	CTPS1 CTPS	LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18615	Y170	Sugiyama	NELFE RD RDBP	GEEAEGPGAGDGPPRsFDWGyEERSGAHSsAsPPRsRSRDR
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P22392	Y151	Sugiyama	NME2 NM23B	SLWFKPEELVDyKSCAHDWVyE___________________
P23528	Y140	Sugiyama	CFL1 CFL	SKDAIKKKLtGIKHELQANCyEEVKDRCTLAEKLGGsAVIs
P25398	Y127	Sugiyama	RPS12	sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P29692	T147	Sugiyama	EEF1D EF1D	PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P31943	Y266	Sugiyama	HNRNPH1 HNRPH HNRPH1	yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P34931	Y43	Sugiyama	HSPA1L	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P39023	S265	Sugiyama	RPL3 OK/SW-cl.32	HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P42166	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46734	S218	GPS6\|ELM\|iPTMNet\|EPSD\|PSP	MAP2K3 MEK3 MKK3 PRKMK3 SKK2	INKEGHVKMCDFGISGyLVDsVAKtMDAGCKPYMAPERINP
P46734	S286	Sugiyama	MAP2K3 MEK3 MKK3 PRKMK3 SKK2	FPYESWGTPFQQLKQVVEEPsPQLPADRFSPEFVDFTAQCL
P46734	T222	GPS6\|ELM\|iPTMNet\|EPSD\|PSP	MAP2K3 MEK3 MKK3 PRKMK3 SKK2	GHVKMCDFGISGyLVDsVAKtMDAGCKPYMAPERINPELNQ
P47712	S727	Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48741	Y43	Sugiyama	HSPA7 HSP70B	FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P53778	T183	GPS6\|ELM\|iPTMNet\|EPSD	MAPK12 ERK6 SAPK3	EDCELKILDFGLARQADsEMtGyVVtRWYRAPEVILNWMRY
P53778	Y185	ELM\|iPTMNet\|EPSD	MAPK12 ERK6 SAPK3	CELKILDFGLARQADsEMtGyVVtRWYRAPEVILNWMRYTQ
P54652	Y42	Sugiyama	HSPA2	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55795	Y266	Sugiyama	HNRNPH2 FTP3 HNRPH2	YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P60174	Y209	Sugiyama	TPI1 TPI	LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P61604	Y100	Sugiyama	HSPE1	KVVLDDKDyFLFRDGDILGKyVD__________________
P62191	Y439	Sugiyama	PSMC1	FKKSKENVLyKKQEGtPEGLyL___________________
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P63173	T14	Sugiyama	RPL38	_______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220	Y53	Sugiyama	RPS21	QMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRLA
P85037	S445	Sugiyama	FOXK1 MNF	GLMsPRsGGLQtPECLsREGsPIPHDPEFGsKLASVPEYRY
Q00613	S363	Sugiyama	HSF1 HSTF1	AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q00839	Y260	Sugiyama	HNRNPU C1orf199 HNRPU SAFA U21.1	GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01130	S212	Sugiyama	SRSF2 SFRS2	PPPVsKRESKSRSRsKsPPKsPEEEGAVss___________
Q01518	T165	Sugiyama	CAP1 CAP	AMAPKPGPYVKEMNDAAMFytNRVLKEYKDVDKKHVDWVKA
Q06830	Y116	Sugiyama	PRDX1 PAGA PAGB TDPX2	GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q13112	S410	Sugiyama	CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7	LNMRtPDtAKKTKsQtHRGssPGPRPVEGtPASRtQDPssP
Q13158	S194	Sugiyama	FADD MORT1 GIG3	ADLVQEVQQARDLQNRsGAMsPMsWNsDAsTSEAS______
Q13247	S303	Sugiyama	SRSF6 SFRS6 SRP55	ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q14568	S53	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14568	Y283	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q15637	S82	Sugiyama	SF1 ZFM1 ZNF162	TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q15759	T180	GPS6\|EPSD	MAPK11 PRKM11 SAPK2 SAPK2B	EDCELRILDFGLARQADEEMtGyVAtRWYRAPEIMLNWMHY
Q15759	Y182	EPSD	MAPK11 PRKM11 SAPK2 SAPK2B	CELRILDFGLARQADEEMtGyVAtRWYRAPEIMLNWMHYNQ
Q16539	T180	GPS6\|SIGNOR\|EPSD\|PSP	MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	EDCELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHY
Q16539	Y182	SIGNOR\|EPSD\|PSP	MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	CELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHYNQ
Q58FF8	Y198	Sugiyama	HSP90AB2P HSP90BB	DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q6GYQ0	T1002	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	TITGSESASPVHSPLGSRsQtPsPSTLNIDHMEQKDLQLDE
Q6UN15	S492	Sugiyama	FIP1L1 FIP1 RHE	DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15	S496	Sugiyama	FIP1L1 FIP1 RHE	DRERERTRERERERDHsPtPsVFNsDEERyRYREYAERGYE
Q6UN15	T494	Sugiyama	FIP1L1 FIP1 RHE	DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q7Z2W4	T273	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	FFQGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDL
Q8IWX8	S815	Sugiyama	CHERP DAN26 SCAF6	RSQSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIP
Q8IWX8	S817	Sugiyama	CHERP DAN26 SCAF6	QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IWX8	T819	Sugiyama	CHERP DAN26 SCAF6	RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8N684	T203	Sugiyama	CPSF7	GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q96CT7	Y38	Sugiyama	CCDC124	RRAEAKAAADAKKQKELEDAyWKDDDKHVMRKEQRKEEKEK
Q96S44	T8	Sugiyama	TP53RK C20orf64 PRPK	_____________MAAARAttPADGEEPAPEAEALAAARER
Q99759	S340	Sugiyama	MAP3K3 MAPKKK3 MEKK3	ENMGLAVQYLDPRGRLRsADsENALsVQERNVPTKsPsAPI
Q9BTA9	S525	Sugiyama	WAC KIAA1844	QGHEPVsPRSLQRsssQRsPsPGPNHtsNssNAsNATVVPQ
Q9C0C2	S672	Sugiyama	TNKS1BP1 KIAA1741 TAB182	TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H6F5	S91	Sugiyama	CCDC86 CYCLON	RLQQGAGLEsPQGQPEPGAAsPQRQQDLHLEsPQRQPEysP
Q9H7N4	S498	Sugiyama	SCAF1 SFRS19 SRA1	GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4	S500	Sugiyama	SCAF1 SFRS19 SRA1	LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9NWB6	S77	Sugiyama	ARGLU1	RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S1648	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35	S876	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	tsPQANEQsVtPQRRsCFEssPDPELKsRtPsRHsCsGssP