MAP2K6

All methods over the ±5 window, side by side.

PSPA (TYR)

CDDM

MLP-attr

TYR version of PSPA with Y as phospho-acceptor

PSPA measures pT, so at flanking positions the pS row is a duplicate of the pT row. At position 0 the acceptor identity (pS, pT, pY) is genuine.

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Position-wise Probabilities (±5 window)

Log-Odds (±5 window)

Motifs stratified by phospho-acceptor (S / T / Y)

K-means sub-motif clusters

Signed attribution PSSM distilled from the CDDM discriminative MLP (in-silico saturation mutagenesis). Letters above 0 are enriched, below are depleted; this is not a probability distribution.

MLP-attribution PSSM (±5, signed)

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substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	Y940	Sugiyama	POTEF A26C1B	ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00165	S153	Sugiyama	HAX1 HS1BP1	PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O14545	S327	Sugiyama	TRAFD1 FLN29	DHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQQAAS
O15264	T180	GPS6\|SIGNOR\|EPSD\|PSP	MAPK13 PRKM13 SAPK4	EDCELKILDFGLARHADAEMtGyVVtRWYRAPEVILSWMHY
O15264	Y182	SIGNOR\|PSP	MAPK13 PRKM13 SAPK4	CELKILDFGLARHADAEMtGyVVtRWYRAPEVILSWMHYNQ
O60361	Y136	Sugiyama	NME2P1	SLRFKPEELVDYKSCAHDWVyE___________________
O60716	S252	Sugiyama	CTNND1 KIAA0384	sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
P00558	T168	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P07195	S320	Sugiyama	LDHB	GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07205	T168	Sugiyama	PGK2 PGKB	EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07237	Y94	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	Y309	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P08238	Y305	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P17812	S575	Sugiyama	CTPS1 CTPS	LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P22392	Y151	Sugiyama	NME2 NM23B	SLWFKPEELVDyKSCAHDWVyE___________________
P23434	Y139	Sugiyama	GCSH	EVTEINEALAENPGLVNKSCyEDGWLIKMtLsNPsELDELM
P25398	Y127	Sugiyama	RPS12	sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P31943	Y266	Sugiyama	HNRNPH1 HNRPH HNRPH1	yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818	S719	Sugiyama	USP8 KIAA0055 UBPY	KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P42166	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P52564	S207	EPSD\|PSP	MAP2K6 MEK6 MKK6 PRKMK6 SKK3	INALGQVKMCDFGISGyLVDsVAKtIDAGCKPyMAPERINP
P52564	S26	Sugiyama	MAP2K6 MEK6 MKK6 PRKMK6 SKK3	GKKRNPGLKIPKEAFEQPQtsstPPRDLDsKACISIGNQNF
P52564	S27	Sugiyama	MAP2K6 MEK6 MKK6 PRKMK6 SKK3	KKRNPGLKIPKEAFEQPQtsstPPRDLDsKACISIGNQNFE
P52564	T25	Sugiyama	MAP2K6 MEK6 MKK6 PRKMK6 SKK3	KGKKRNPGLKIPKEAFEQPQtsstPPRDLDsKACISIGNQN
P52564	T28	Sugiyama	MAP2K6 MEK6 MKK6 PRKMK6 SKK3	KRNPGLKIPKEAFEQPQtsstPPRDLDsKACISIGNQNFEV
P52564	Y219	EPSD\|PSP	MAP2K6 MEK6 MKK6 PRKMK6 SKK3	GISGyLVDsVAKtIDAGCKPyMAPERINPELNQKGYSVKSD
P53778	T183	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAPK12 ERK6 SAPK3	EDCELKILDFGLARQADsEMtGyVVtRWYRAPEVILNWMRY
P53778	Y185	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAPK12 ERK6 SAPK3	CELKILDFGLARQADsEMtGyVVtRWYRAPEVILNWMRYTQ
P55795	Y266	Sugiyama	HNRNPH2 FTP3 HNRPH2	YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P60174	Y209	Sugiyama	TPI1 TPI	LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P60709	Y240	Sugiyama	ACTB	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736	Y242	Sugiyama	ACTA2 ACTSA ACTVS GIG46	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63220	Y53	Sugiyama	RPS21	QMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRLA
P63261	Y240	Sugiyama	ACTG1 ACTG	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267	Y241	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032	Y242	Sugiyama	ACTC1 ACTC	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133	Y242	Sugiyama	ACTA1 ACTA	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
Q00613	S363	Sugiyama	HSF1 HSTF1	AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q01518	T165	Sugiyama	CAP1 CAP	AMAPKPGPYVKEMNDAAMFytNRVLKEYKDVDKKHVDWVKA
Q06830	Y116	Sugiyama	PRDX1 PAGA PAGB TDPX2	GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q12913	S843	Sugiyama	PTPRJ DEP1	PNITSVSHNSVKVKFSGFEAsHGPIKAYAVILTTGEAGHPS
Q13247	S303	Sugiyama	SRSF6 SFRS6 SRP55	ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q14152	S988	Sugiyama	EIF3A EIF3S10 KIAA0139	PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14765	S721	SIGNOR\|iPTMNet\|EPSD	STAT4	ISTIRSDSTEPHsPSDLLPMsPSVYAVLRENLsPTTIETAM
Q15080	S67	Sugiyama	NCF4 SH3PXD4	TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15637	S82	Sugiyama	SF1 ZFM1 ZNF162	TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q15759	T180	GPS6\|EPSD	MAPK11 PRKM11 SAPK2 SAPK2B	EDCELRILDFGLARQADEEMtGyVAtRWYRAPEIMLNWMHY
Q15759	Y182	EPSD	MAPK11 PRKM11 SAPK2 SAPK2B	CELRILDFGLARQADEEMtGyVAtRWYRAPEIMLNWMHYNQ
Q16539	T180	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	EDCELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHY
Q16539	Y182	SIGNOR\|iPTMNet\|EPSD\|PSP	MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	CELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHYNQ
Q562R1	Y241	Sugiyama	ACTBL2	ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q6GYQ0	T1002	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	TITGSESASPVHSPLGSRsQtPsPSTLNIDHMEQKDLQLDE
Q6S8J3	Y940	Sugiyama	POTEE A26C1A POTE2	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6UN15	S492	Sugiyama	FIP1L1 FIP1 RHE	DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q7L2J0	S216	Sugiyama	MEPCE BCDIN3	NLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDIt
Q7L2J0	T213	Sugiyama	MEPCE BCDIN3	DPLNLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPK
Q7Z2W4	T273	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	FFQGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDL
Q8IWX8	S817	Sugiyama	CHERP DAN26 SCAF6	QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IWX8	T819	Sugiyama	CHERP DAN26 SCAF6	RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8N684	T203	Sugiyama	CPSF7	GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q96CT7	Y38	Sugiyama	CCDC124	RRAEAKAAADAKKQKELEDAyWKDDDKHVMRKEQRKEEKEK
Q96MU7	S308	Sugiyama	YTHDC1 KIAA1966 YT521	GSGTDGsDEKKKERKRARGIsPIVFDRsGssAsESYAGsEK
Q96S44	T8	Sugiyama	TP53RK C20orf64 PRPK	_____________MAAARAttPADGEEPAPEAEALAAARER
Q99759	S337	Sugiyama	MAP3K3 MAPKKK3 MEKK3	tNGENMGLAVQYLDPRGRLRsADsENALsVQERNVPTKsPs
Q9BYX7	Y240	Sugiyama	POTEKP ACTBL3 FKSG30	ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9H7N4	S498	Sugiyama	SCAF1 SFRS19 SRA1	GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4	S500	Sugiyama	SCAF1 SFRS19 SRA1	LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9NQU5	T564	GPS6\|ELM\|iPTMNet\|EPSD	PAK6 PAK5	DFGFCAQISKDVPKRKsLVGtPyWMAPEVISRSLYATEVDI
Q9NQU5	Y566	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PAK6 PAK5	GFCAQISKDVPKRKsLVGtPyWMAPEVISRSLYATEVDIWS
Q9NWB6	S77	Sugiyama	ARGLU1	RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9ULV5	T471	SIGNOR\|EPSD\|PSP	HSF4	LLLDVQAALGGPALGLPGALtIYSTPESRTASYLGPEASPS
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S2046	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	IRRRsRsRtPLLPRKRsRsRsPLAIRRRSRSRTPRTARGKR
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9Y2V2	S30	Sugiyama	CARHSP1	QPPtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRt
Q9Y2V2	S32	Sugiyama	CARHSP1	PtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRtFs