MAP2K7

All methods over the ±5 window, side by side.

PSPA (TYR)

CDDM

MLP-attr

TYR version of PSPA with Y as phospho-acceptor

PSPA measures pT, so at flanking positions the pS row is a duplicate of the pT row. At position 0 the acceptor identity (pS, pT, pY) is genuine.

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Position-wise Probabilities (±5 window)

Log-Odds (±5 window)

Motifs stratified by phospho-acceptor (S / T / Y)

K-means sub-motif clusters

Signed attribution PSSM distilled from the CDDM discriminative MLP (in-silico saturation mutagenesis). Letters above 0 are enriched, below are depleted; this is not a probability distribution.

MLP-attribution PSSM (±5, signed)

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substrate_uniprot	site	source	substrate_genes	site_seq
O00165	S153	Sugiyama	HAX1 HS1BP1	PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O14733	S277	Sugiyama	MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4	IKLCDFGIsGRLVDsKAKtRsAGCAAYMAPERIDPPDPTKP
O14733	S61	Sugiyama	MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4	PtLQLPLANDGGsRsPssEssPQHPtPPARPRHMLGLPSTL
O14733	S89	Sugiyama	MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4	ARPRHMLGLPSTLFTPRSMEsIEIDQKLQEIMKQTGyLTIG
O14733	T275	Sugiyama	MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4	GQIKLCDFGIsGRLVDsKAKtRsAGCAAYMAPERIDPPDPT
O14733	T66	Sugiyama	MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4	PLANDGGsRsPssEssPQHPtPPARPRHMLGLPSTLFTPRS
O14733	Y105	Sugiyama	MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4	RSMEsIEIDQKLQEIMKQTGyLTIGGQRYQAEINDLENLGE
O14974	S695	Sugiyama	PPP1R12A MBS MYPT1	DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O15264	T180	GPS6\|SIGNOR\|EPSD	MAPK13 PRKM13 SAPK4	EDCELKILDFGLARHADAEMtGyVVtRWYRAPEVILSWMHY
O15264	Y182	SIGNOR	MAPK13 PRKM13 SAPK4	CELKILDFGLARHADAEMtGyVVtRWYRAPEVILSWMHYNQ
O43852	T196	Sugiyama	CALU	FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O60716	S252	Sugiyama	CTNND1 KIAA0384	sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75131	S242	Sugiyama	CPNE3 CPN3 KIAA0636	SHDLIGTFQTTMTKLKEAsRssPVEFECINEKKRQKKKSYK
P00558	Y161	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P04075	S354	Sugiyama	ALDOA ALDA	ANsLACQGKytPsGQAGAAAsEsLFVsNHAy__________
P04075	S356	Sugiyama	ALDOA ALDA	sLACQGKytPsGQAGAAAsEsLFVsNHAy____________
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S360	Sugiyama	ALDOA ALDA	QGKytPsGQAGAAAsEsLFVsNHAy________________
P04075	Y364	Sugiyama	ALDOA ALDA	tPsGQAGAAAsEsLFVsNHAy____________________
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	S321	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE______
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P07205	Y161	Sugiyama	PGK2 PGKB	KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P08238	S460	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P13639	S587	Sugiyama	EEF2 EF2	CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P13639	S593	Sugiyama	EEF2 EF2	SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639	Y579	Sugiyama	EEF2 EF2	KDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKH
P14314	T115	Sugiyama	PRKCSH G19P1	GVCDCCDGtDEyNsGVICENtCKEKGRKEREsLQQMAEVtR
P14618	S202	Sugiyama	PKM OIP3 PK2 PK3 PKM2	SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14625	S64	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P17812	S575	Sugiyama	CTPS1 CTPS	LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P21333	S1084	Sugiyama	FLNA FLN FLN1	PTKPSKVKAFGPGLQGGsAGsPARFtIDTKGAGTGGLGLTV
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P35269	T389	Sugiyama	GTF2F1 RAP74	PPKRERKPsGGSSRGNsRPGtPsAEGGstsstLRAAASKLE
P35568	S312	SIGNOR	IRS1	PPPSQVGLTRRsRtEsItAtsPAsMVGGKPGsFRVRAssDG
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818	S719	Sugiyama	USP8 KIAA0055 UBPY	KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P42166	S159	Sugiyama	TMPO LAP2	RKLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsND
P42166	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167	S159	Sugiyama	TMPO LAP2	RKLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSND
P42167	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P45983	T183	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAPK8 JNK1 PRKM8 SAPK1 SAPK1C	CTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYK
P45983	Y185	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAPK8 JNK1 PRKM8 SAPK1 SAPK1C	LKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYKEN
P45984	S407	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAPK9 JNK2 PRKM9 SAPK1A	PSQSSSINDISSMSTEQtLAsDTDSSLDASTGPLEGCR___
P45984	T183	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAPK9 JNK2 PRKM9 SAPK1A	CTLKILDFGLARTACTNFMMtPyVVtRYYRAPEVILGMGYK
P45984	T404	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAPK9 JNK2 PRKM9 SAPK1A	NATPSQSSSINDISSMSTEQtLAsDTDSSLDASTGPLEGCR
P45984	Y185	SIGNOR\|iPTMNet\|EPSD	MAPK9 JNK2 PRKM9 SAPK1A	LKILDFGLARTACTNFMMtPyVVtRYYRAPEVILGMGYKEN
P52272	S633	Sugiyama	HNRNPM HNRPM NAGR1	GGGGAsFDRAIEMERGNFGGsFAGsFGGAGGHAPGVARKAC
P52272	S637	Sugiyama	HNRNPM HNRPM NAGR1	AsFDRAIEMERGNFGGsFAGsFGGAGGHAPGVARKACQIFV
P53779	T221	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAPK10 JNK3 JNK3A PRKM10 SAPK1B	CTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYK
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	T324	Sugiyama	ACTB	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61254	T8	Sugiyama	RPL26	_____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736	T326	Sugiyama	ACTA2 ACTSA ACTVS GIG46	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	T324	Sugiyama	ACTG1 ACTG	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267	T325	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	T326	Sugiyama	ACTC1 ACTC	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	T326	Sugiyama	ACTA1 ACTA	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
Q00613	S363	Sugiyama	HSF1 HSTF1	AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q13158	S194	SIGNOR\|EPSD\|PSP	FADD MORT1 GIG3	ADLVQEVQQARDLQNRsGAMsPMsWNsDAsTSEAS______
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q15637	S82	Sugiyama	SF1 ZFM1 ZNF162	TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q6UN15	S492	Sugiyama	FIP1L1 FIP1 RHE	DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q7L2J0	S217	Sugiyama	MEPCE BCDIN3	LNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDItD
Q7L2J0	S69	Sugiyama	MEPCE BCDIN3	RGPGRCAPsAGsPAAAVGREsPGAAAtsSSGPQAQQHRGGG
Q7L2J0	T213	Sugiyama	MEPCE BCDIN3	DPLNLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPK
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q8IZ21	S118	Sugiyama	PHACTR4 PRO2963	PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N684	T203	Sugiyama	CPSF7	GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q96GM8	S420	Sugiyama	TOE1	KNDLEMGIKAARPEIADRATsEVPGsQAsPNPVPGDGLHRA
Q96MU7	S308	Sugiyama	YTHDC1 KIAA1966 YT521	GSGTDGsDEKKKERKRARGIsPIVFDRsGssAsESYAGsEK
Q96S44	T8	Sugiyama	TP53RK C20orf64 PRPK	_____________MAAARAttPADGEEPAPEAEALAAARER
Q99759	T153	Sugiyama	MAP3K3 MAPKKK3 MEKK3	HSGVSRQVRIKAsQsAGDINtIyQPPEPRsRHLsVssQNPG
Q9BQE3	S439	Sugiyama	TUBA1C TUBA6	SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BTA9	S525	Sugiyama	WAC KIAA1844	QGHEPVsPRSLQRsssQRsPsPGPNHtsNssNAsNATVVPQ
Q9C0C2	S672	Sugiyama	TNKS1BP1 KIAA1741 TAB182	TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H4A3	S1261	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H6F5	S91	Sugiyama	CCDC86 CYCLON	RLQQGAGLEsPQGQPEPGAAsPQRQQDLHLEsPQRQPEysP
Q9H7N4	S498	Sugiyama	SCAF1 SFRS19 SRA1	GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4	S500	Sugiyama	SCAF1 SFRS19 SRA1	LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9NPI6	S525	Sugiyama	DCP1A SMIF	SVFQQTVTRSSDLERKAssPsPLtIGtPEsQRKPSIILSKs
Q9UMZ2	S1087	Sugiyama	SYNRG AP1GBP1 SYNG	QGSHKRsLsLGDKEIsRssPsPALEQPFRDRsNtLNEKPAL
Q9UNX3	T8	Sugiyama	RPL26L1 RPL26P1	_____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S1648	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35	S876	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	tsPQANEQsVtPQRRsCFEssPDPELKsRtPsRHsCsGssP
Q9UQ35	T328	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	APFsEPGttstQRPssPEtAtKQPssPYEDKDKDKKEKsAt