MEKK3

All methods over the ±5 window, side by side.

PSPA

CDDM

MLP-attr

Normalized values from positional scanning peptide array

PSPA measures pT, so at flanking positions the pS row is a duplicate of the pT row. At position 0 the acceptor identity (pS, pT, pY) is genuine.

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Position-wise Probabilities (±5 window)

Log-Odds (±5 window)

Motifs stratified by phospho-acceptor (S / T / Y)

K-means sub-motif clusters

Signed attribution PSSM distilled from the CDDM discriminative MLP (in-silico saturation mutagenesis). Letters above 0 are enriched, below are depleted; this is not a probability distribution.

MLP-attribution PSSM (±5, signed)

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substrate_uniprot	site	source	substrate_genes	site_seq
O43852	T89	Sugiyama	CALU	sKERLGKIVSKIDGDKDGFVtVDELKDWIKFAQKRWIyEDV
O60220	S94	Sugiyama	TIMM8A DDP DDP1 TIM8A	SQFILNRLEQTQKSKPVFSEsLsD_________________
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00558	T168	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406	T246	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05976	T146	Sugiyama	MYL1	QATYEDFVEGLRVFDKEGNGtVMGAELRHVLATLGEKMKEE
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195	T18	Sugiyama	LDHB	___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205	T168	Sugiyama	PGK2 PGKB	EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P08151	S1078	EPSD\|PSP	GLI1 GLI	GLSPPPSHDQRGSsGHtPPPsGPPNMAVGNMsVLLRSLPGE
P08151	S201	EPSD\|PSP	GLI1 GLI	SELDMLVGKCREEPLEGDMSsPNsTGIQDPLLGMLDGREDL
P08151	S204	EPSD\|PSP	GLI1 GLI	DMLVGKCREEPLEGDMSsPNsTGIQDPLLGMLDGREDLERE
P08151	S243	EPSD\|PSP	GLI1 GLI	REEKREPESVYETDCRWDGCsQEFDSQEQLVHHINSEHIHG
P08151	S968	EPSD\|PSP	GLI1 GLI	YGPGFGPNLPNHKSGSYPTPsPCHENFVVGANRAsHRAAAP
P08151	T1074	EPSD\|PSP	GLI1 GLI	DEPQGLSPPPSHDQRGSsGHtPPPsGPPNMAVGNMsVLLRS
P08590	T147	Sugiyama	MYL3	tGtYEDFVEGLRVFDKEGNGtVMGAELRHVLAtLGERLtED
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09972	T125	Sugiyama	ALDOC ALDC	VGIKVDKGVVPLAGtDGEtttQGLDGLsERCAQYKKDGADF
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142	T64	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P31327	T45	Sugiyama	CPS1	AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P35579	T1208	Sugiyama	MYH9	QEMRQKHsQAVEELAEQLEQtKRVKANLEKAKQtLENERGE
P38117	T172	Sugiyama	ETFB FP585	QVTLEGDKLKVEREIDGGLEtLRLKLPAVVTADLRLNEPRy
P38646	T120	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646	Y118	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P45985	S257	GPS6	MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1	LDRSGNIKLCDFGIsGQLVDsIAKtRDAGCRPyMAPERIDP
P45985	T261	GPS6	MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1	GNIKLCDFGIsGQLVDsIAKtRDAGCRPyMAPERIDPSASR
P46734	S218	SIGNOR	MAP2K3 MEK3 MKK3 PRKMK3 SKK2	INKEGHVKMCDFGISGyLVDsVAKtMDAGCKPYMAPERINP
P48454	T153	Sugiyama	PPP3CC CALNA3 CNA3	KINHPKTLFLLRGNHECRHLtDYFtFKQECRIKYSEQVYDA
P48454	T157	Sugiyama	PPP3CC CALNA3 CNA3	PKTLFLLRGNHECRHLtDYFtFKQECRIKYSEQVYDACMET
P52948	S683	Sugiyama	NUP98 ADAR2	IAKPIPQtPEsAGNKHsNsNsVDDtIVALNMRAALRNGLEG
P53805	S163	EPSD\|PSP	RCAN1 ADAPT78 CSP1 DSC1 DSCR1	TLHIGSSHLAPPNPDKQFLIsPPAsPPVGWKQVEDAtPVIN
P53805	S167	SIGNOR\|EPSD\|PSP	RCAN1 ADAPT78 CSP1 DSC1 DSCR1	GSSHLAPPNPDKQFLIsPPAsPPVGWKQVEDAtPVINYDLL
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P55854	S27	Sugiyama	SUMO3 SMT3A SMT3H1	KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	T324	Sugiyama	ACTB	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61956	S28	Sugiyama	SUMO2 SMT3B SMT3H2	EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62424	T84	Sugiyama	RPL7A SURF-3 SURF3	QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736	T326	Sugiyama	ACTA2 ACTSA ACTVS GIG46	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62826	T21	Sugiyama	RAN ARA24 OK/SW-cl.81	MAAQGEPQVQFKLVLVGDGGtGKttFVKRHLtGEFEKKyVA
P62942	T7	Sugiyama	FKBP1A FKBP1 FKBP12	______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63220	S31	Sugiyama	RPS21	LYVPRKCSASNRIIGAKDHAsIQMNVAEVDKVTGRFNGQFK
P63220	S68	Sugiyama	RPS21	GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	T324	Sugiyama	ACTG1 ACTG	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267	T325	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P67809	T108	Sugiyama	YBX1 NSEP1 YB1	QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	T326	Sugiyama	ACTC1 ACTC	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	T326	Sugiyama	ACTA1 ACTA	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363	Y432	Sugiyama	TUBA1B	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P78371	T246	Sugiyama	CCT2 99D8.1 CCTB	VNQPKRIENAKILIANtGMDtDKIKIFGsRVRVDstAKVAE
Q13283	T241	Sugiyama	G3BP1 G3BP	ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q6EEV6	S28	Sugiyama	SUMO4 SMT3H4	EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC
Q6PCE3	S175	Sugiyama	PGM2L1 BM32A	PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q71U36	Y432	Sugiyama	TUBA1A TUBA3	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q7Z2W4	T294	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	PsPDQIsHRAsLEDAPVDDLtRKFtyLGsQDRARPPsGsSK
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8IWI9	Y864	Sugiyama	MGA KIAA0518 MAD5	FSSNAPTSPVVYQLPTKStsyVRtLDsVLKKQSTISPSTSY
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q99759	S145	Sugiyama	MAP3K3 MAPKKK3 MEKK3	RNHNsssPHSGVSRQVRIKAsQsAGDINtIyQPPEPRsRHL
Q99759	S147	Sugiyama	MAP3K3 MAPKKK3 MEKK3	HNsssPHSGVSRQVRIKAsQsAGDINtIyQPPEPRsRHLsV
Q99759	S166	Sugiyama	MAP3K3 MAPKKK3 MEKK3	QsAGDINtIyQPPEPRsRHLsVssQNPGRssPPPGYVPERQ
Q99759	S175	Sugiyama	MAP3K3 MAPKKK3 MEKK3	yQPPEPRsRHLsVssQNPGRssPPPGYVPERQQHIARQGSY
Q99759	S176	Sugiyama	MAP3K3 MAPKKK3 MEKK3	QPPEPRsRHLsVssQNPGRssPPPGYVPERQQHIARQGSYT
Q99759	S250	Sugiyama	MAP3K3 MAPKKK3 MEKK3	SLDRSADSPSFRKSRMSRAQsFPDNRQEysDREtQLYDKGV
Q99759	S259	Sugiyama	MAP3K3 MAPKKK3 MEKK3	SFRKSRMSRAQsFPDNRQEysDREtQLYDKGVKGGTYPRRY
Q99759	S337	Sugiyama	MAP3K3 MAPKKK3 MEKK3	tNGENMGLAVQYLDPRGRLRsADsENALsVQERNVPTKsPs
Q99759	S340	Sugiyama	MAP3K3 MAPKKK3 MEKK3	ENMGLAVQYLDPRGRLRsADsENALsVQERNVPTKsPsAPI
Q99759	S345	Sugiyama	MAP3K3 MAPKKK3 MEKK3	AVQYLDPRGRLRsADsENALsVQERNVPTKsPsAPINWRRG
Q99759	S399	Sugiyama	MAP3K3 MAPKKK3 MEKK3	CYDVDtGRELASKQVQFDPDsPETSKEVSALECEIQLLKNL
Q99759	S526	GPS6\|SIGNOR\|EPSD	MAP3K3 MAPKKK3 MEKK3	GDFGASKRLQtICMsGTGMRsVtGtPYWMSPEVISGEGYGR
Q99759	T153	Sugiyama	MAP3K3 MAPKKK3 MEKK3	HSGVSRQVRIKAsQsAGDINtIyQPPEPRsRHLsVssQNPG
Q99759	T263	Sugiyama	MAP3K3 MAPKKK3 MEKK3	SRMSRAQsFPDNRQEysDREtQLYDKGVKGGTYPRRYHVSV
Q99759	T384	Sugiyama	MAP3K3 MAPKKK3 MEKK3	RGKLLGQGAFGRVYLCYDVDtGRELASKQVQFDPDsPETSK
Q99759	T462	Sugiyama	MAP3K3 MAPKKK3 MEKK3	FMEYMPGGSVKDQLKAYGALtESVTRKYTRQILEGMSYLHS
Q99759	Y155	Sugiyama	MAP3K3 MAPKKK3 MEKK3	GVSRQVRIKAsQsAGDINtIyQPPEPRsRHLsVssQNPGRs
Q99759	Y258	Sugiyama	MAP3K3 MAPKKK3 MEKK3	PSFRKSRMSRAQsFPDNRQEysDREtQLYDKGVKGGTYPRR
Q9H173	T125	Sugiyama	SIL1 UNQ545/PRO836	QYEDKFRNNLKGKRLDINtNtytsQDLKSALAKFKEGAEME
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2T7	T143	Sugiyama	YBX2 CSDA3 MSY2	QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y2U5	S393	Sugiyama	MAP3K2 MAPKKK2 MEKK2	CYDVDTGRELAVKQVQFDPDsPETSKEVNALECEIQLLKNL
Q9Y490	T2204	Sugiyama	TLN1 KIAA1027 TLN	MATAKAVAAGNSCRQEDVIAtANLSRRAIADMLRACKEAAy
Q9Y4G6	T2205	Sugiyama	TLN2 KIAA0320	MATAKAVAAGNSCRQEDVIAtANLSRKAVSDMLTACKQASF