PAK4

All methods over the ±5 window, side by side.

PSPA

CDDM

MLP-attr

Normalized values from positional scanning peptide array

PSPA measures pT, so at flanking positions the pS row is a duplicate of the pT row. At position 0 the acceptor identity (pS, pT, pY) is genuine.

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Position-wise Probabilities (±5 window)

Log-Odds (±5 window)

Motifs stratified by phospho-acceptor (S / T / Y)

K-means sub-motif clusters

Signed attribution PSSM distilled from the CDDM discriminative MLP (in-silico saturation mutagenesis). Letters above 0 are enriched, below are depleted; this is not a probability distribution.

MLP-attribution PSSM (±5, signed)

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substrate_uniprot	site	source	substrate_genes	site_seq
O00401	S484	EPSD\|PSP	WASL	TSGIVGALMEVMQKRSKAIHssDEDEDEDDEEDFEDDDEWE
O00401	S485	EPSD\|PSP	WASL	SGIVGALMEVMQKRSKAIHssDEDEDEDDEEDFEDDDEWED
O14579	S99	Sugiyama	COPE	PELQAVRMFADyLAHEsRRDsIVAELDREMsRSVDVTNTTF
O14713	S10	GPS6\|PSP	ITGB1BP1 ICAP1	___________MFRKGKKRHssSsSQSSEISTKSKsVDssL
O15013	S1232	Sugiyama	ARHGEF10 KIAA0294	VKFIVLATALHEKDKDKsRDsLAPGPEPQDEDQKDALPSGG
O15085	T1292	Sugiyama	ARHGEF11 KIAA0380	GERPEQEDMGLCSLEHLPPRtRNsGIWEsPELDRNLAEDAS
O43379	T46	Sugiyama	WDR62 C19orf14	PARRGQssPPPAPPICLRRRtRLstAsEETVQNRVsLEKVL
O43623	S158	SIGNOR\|PSP	SNAI2 SLUG SLUGH	STFSGLAKHKQLHCDAQSRKsFSCKYCDKEYVSLGALKMHI
O43623	S254	SIGNOR\|PSP	SNAI2 SLUG SLUGH	THsDVKKYQCKNCsKTFsRMsLLHKHEESGCCVAH______
O95678	S162	Sugiyama	KRT75 K6HF KB18	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O96013	S104	iPTMNet\|EPSD	PAK4 KIAA1142	LLLDEFENMSVTRsNsLRRDsPPPPARARQENGMPEEPATT
O96013	S12	Sugiyama	PAK4 KIAA1142	_________MFGKRKKRVEIsAPsNFEHRVHTGFDQHEQKF
O96013	S148	iPTMNet\|EPSD	PAK4 KIAA1142	GPGKAGSRGRFAGHsEAGGGsGDRRRAGPEKRPKSSREGsG
O96013	S15	Sugiyama	PAK4 KIAA1142	______MFGKRKKRVEIsAPsNFEHRVHTGFDQHEQKFTGL
O96013	S167	iPTMNet\|EPSD	PAK4 KIAA1142	GsGDRRRAGPEKRPKSSREGsGGPQESSRDKRPLsGPDVGt
O96013	S181	iPTMNet\|EPSD\|Sugiyama	PAK4 KIAA1142	KSSREGsGGPQESSRDKRPLsGPDVGtPQPAGLAsGAKLAA
O96013	S195	Sugiyama	PAK4 KIAA1142	RDKRPLsGPDVGtPQPAGLAsGAKLAAGRPFNtyPRADTDH
O96013	S243	Sugiyama	PAK4 KIAA1142	EPHDVAPNGPSAGGLAIPQSssSSSRPPTRARGAPsPGVLG
O96013	S244	Sugiyama	PAK4 KIAA1142	PHDVAPNGPSAGGLAIPQSssSSSRPPTRARGAPsPGVLGP
O96013	S258	iPTMNet\|EPSD	PAK4 KIAA1142	AIPQSssSSSRPPTRARGAPsPGVLGPHAsEPQLAPPACtP
O96013	S291	iPTMNet\|EPSD	PAK4 KIAA1142	LAPPACtPAAPAVPGPPGPRsPQREPQRVSHEQFRAALQLV
O96013	S41	Sugiyama	PAK4 KIAA1142	VHTGFDQHEQKFTGLPRQWQsLIEESARRPKPLVDPACITS
O96013	S474	GPS6\|SIGNOR\|EPSD\|PSP	PAK4 KIAA1142	VKLSDFGFCAQVSKEVPRRKsLVGtPYWMAPELISRLPYGP
O96013	S99	iPTMNet\|EPSD	PAK4 KIAA1142	DGALTLLLDEFENMSVTRsNsLRRDsPPPPARARQENGMPE
O96013	T187	Sugiyama	PAK4 KIAA1142	sGGPQESSRDKRPLsGPDVGtPQPAGLAsGAKLAAGRPFNt
O96013	T207	iPTMNet\|EPSD	PAK4 KIAA1142	tPQPAGLAsGAKLAAGRPFNtyPRADTDHPSRGAQGEPHDV
O96013	T478	iPTMNet\|EPSD	PAK4 KIAA1142	DFGFCAQVSKEVPRRKsLVGtPYWMAPELISRLPYGPEVDI
P02538	S176	Sugiyama	KRT6A K6A KRT6D	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P03372	S305	EPSD\|PSP	ESR1 ESR NR3A1	DMRAANLWPsPLMIKRSKKNsLALSLtADQMVSALLDAEPP
P04075	S336	Sugiyama	ALDOA ALDA	GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04259	S176	Sugiyama	KRT6B K6B KRTL1	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04637	S215	EPSD\|PSP	TP53 P53	IRVEGNLRVEYLDDRNtFRHsVVVPyEPPEVGSDCTTIHYN
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05787	S104	Sugiyama	KRT8 CYK8	IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787	S330	Sugiyama	KRT8 CYK8	MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P07101	S71	PSP	TH TYH	APAASYTPTPRsPRFIGRRQsLIEDARKEREAAVAAAAAAV
P07954	S46	SIGNOR\|PSP	FH	PGLGGAAVPSFWPPNAARMAsQNSFRIEyDtFGELKVPNDK
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08729	S104	Sugiyama	KRT7 SCL	LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09972	S45	Sugiyama	ALDOC ALDC	APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P12035	S211	Sugiyama	KRT3	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13647	S181	Sugiyama	KRT5	IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P16083	S80	Sugiyama	NQO2 NMOR2	LSNPEVFNyGVEtHEAyKQRsLAsDITDEQKKVREADLVIF
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17987	S374	Sugiyama	TCP1 CCT1 CCTA	ERICDDELILIKNTKARTsAsIILRGANDFMCDEMERSLHD
P18084	S759	SIGNOR\|EPSD\|PSP	ITGB5	LAIWKLLVTIHDRREFAKFQsERsRARYEMAsNPLyRKPIs
P18084	S762	SIGNOR\|EPSD\|PSP	ITGB5	WKLLVTIHDRREFAKFQsERsRARYEMAsNPLyRKPIstHt
P22087	S124	Sugiyama	FBL FIB1 FLRN	DALVTKNLVPGEsVyGEKRVsIsEGDDKIEyRAWNPFRSKL
P24928	S35	Sugiyama	POLR2A POLR2	LRTIKRVQFGVLsPDELKRMsVTEGGIKYPETTEGGRPKLG
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27448	S42	Sugiyama	MARK3 CTAK1 EMK2	GDGRQEVTSRTSRSGARCRNsIAsCADEQPHIGNyRLLKTI
P28698	S27	SIGNOR\|PSP	MZF1 MZF ZNF42 ZSCAN6	GSPDRAPPEDEGPVMVKLEDsEEEGEAALWDPGPEAARLRF
P30048	S199	Sugiyama	PRDX3 AOP1	SGLALRGLFIIDPNGVIKHLsVNDLPVGRSVEETLRLVKAF
P30086	S52	Sugiyama	PEBP1 PBP PEBP	AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30533	S242	Sugiyama	LRPAP1 A2MRAP	TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35222	S675	SIGNOR\|EPSD\|PSP	CTNNB1 CTNNB OK/SW-cl.35 PRO2286	AAAVLFRMSEDKPQDyKKRLsVELtssLFRTEPMAWNETAD
P35908	S191	Sugiyama	KRT2 KRT2A KRT2E	IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P47712	S727	Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48668	S176	Sugiyama	KRT6C KRT6E	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49023	S272	SIGNOR\|EPSD	PXN	QQQtRIsAssAtRELDELMAsLsDFKIQGLEQRADGERCWA
P49736	S229	Sugiyama	MCM2 BM28 CCNL1 CDCL1 KIAA0030	sHGHNVFKERIsDMCKENREsLVVNyEDLAAREHVLAYFLP
P49840	Y279	Sugiyama	GSK3A	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841	Y216	Sugiyama	GSK3B	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P50395	T425	Sugiyama	GDI2 RABGDIB	DAttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53667	T508	EPSD\|PSP	LIMK1 LIMK	EKTQPEGLRSLKKPDRKKRYtVVGNPyWMAPEMINGRSYDE
P53671	T505	PSP	LIMK2	MEKATTKKRtLRKNDRKKRYtVVGNPYWMAPEMLNGKSYDE
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P60709	Y53	Sugiyama	ACTB	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62736	Y55	Sugiyama	ACTA2 ACTSA ACTVS GIG46	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62826	S135	SIGNOR\|EPSD\|PSP	RAN ARA24 OK/SW-cl.81	IPIVLCGNKVDIKDRKVKAKsIVFHRKKNLQyyDIsAKSNy
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63146	S142	Sugiyama	UBE2B RAD6B UBCH1	ANSQAAQLYQENKREYEKRVsAIVEQsWNDS__________
P63261	Y53	Sugiyama	ACTG1 ACTG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267	Y54	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032	Y55	Sugiyama	ACTC1 ACTC	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133	Y55	Sugiyama	ACTA1 ACTA	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
Q01082	S1388	Sugiyama	SPTBN1 SPTB2	TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01196	T207	PSP	RUNX1 AML1 CBFA2	TKPGSLsFSERLSELEQLRRtAMRVsPHHPAPTPNPRAsLN
Q01546	S196	Sugiyama	KRT76 KRT2B KRT2P	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q07866	S524	Sugiyama	KLC1 KLC KNS2	QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM
Q12789	S1865	Sugiyama	GTF3C1	sPPEGQAPPsHsPRGTKRRAsWAsENGEtDAEGTQMtPAKR
Q12789	S1868	Sugiyama	GTF3C1	EGQAPPsHsPRGTKRRAsWAsENGEtDAEGTQMtPAKRPAL
Q13501	S28	Sugiyama	SQSTM1 ORCA OSIL	AYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPCERLL
Q13769	S314	Sugiyama	THOC5 C22orf19 KIAA0983	VDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRPtLGVQLD
Q14432	T311	Sugiyama	PDE3A	RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14CN4	S138	Sugiyama	KRT72 K6IRS2 KB35 KRT6 KRT6IRS2	IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q16236	T369	SIGNOR\|PSP	NFE2L2 NRF2	NTsPSVAsPEHSVESSSYGDtLLGLsDSEVEELDSAPGSVK
Q3SY84	S143	Sugiyama	KRT71 K6IRS1 KB34 KRT6IRS1	IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q5T1M5	S1162	Sugiyama	FKBP15 KIAA0674	EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP
Q5XKE5	S155	Sugiyama	KRT79 K6L KB38 KRT6L	IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6IBS0	S139	Sugiyama	TWF2 PTK9L MSTP011	DELFGTVKDDLSFAGyQKHLssCAAPAPLtsAERELQQIRI
Q7RTS7	S153	Sugiyama	KRT74 K6IRS4 KB37 KRT5C KRT6IRS4	IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z5L9	Y17	Sugiyama	IRF2BP2	____MAAAVAVAAASRRQsCyLCDLPRMPWAMIWDFTEPVC
Q7Z794	S177	Sugiyama	KRT77 KRT1B	IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86VP6	S1221	Sugiyama	CAND1 KIAA0829 TIP120 TIP120A	QISSNPELAAIFESIQKDssstNLEsMDts___________
Q86VP6	S1226	Sugiyama	CAND1 KIAA0829 TIP120 TIP120A	PELAAIFESIQKDssstNLEsMDts________________
Q86VP6	S1230	Sugiyama	CAND1 KIAA0829 TIP120 TIP120A	AIFESIQKDssstNLEsMDts____________________
Q86VP6	T1222	Sugiyama	CAND1 KIAA0829 TIP120 TIP120A	ISSNPELAAIFESIQKDssstNLEsMDts____________
Q86Y46	S145	Sugiyama	KRT73 K6IRS3 KB36 KRT6IRS3	IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8TCS8	S768	Sugiyama	PNPT1 PNPASE	SRKVLQsPAtTVVRTLNDRssIVMGEPIsQSSSNsQ_____
Q92934	S75	EPSD	BAD BBC6 BCL2L8	PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92974	S143	GPS6\|EPSD	ARHGEF2 KIAA0651 LFP40	AIyPsDsFRQsLLGsRRGRssLSLAKsVsttNIAGHFNDEs
Q92974	S896	GPS6\|EPSD	ARHGEF2 KIAA0651 LFP40	ARRPVDPRRRsLPAGDALyLsFNPPQPSRGTDRLDLPVtTR
Q93045	S50	EPSD\|PSP	STMN2 SCG10 SCGN10	RNINIYTYDDMEVKQINKRAsGQAFELILKPPsPISEAPRT
Q969S3	S38	Sugiyama	ZNF622 ZPR9	MQRAHYKTDWHRYNLRRKVAsMAPVTAEGFQERVRAQRAVA
Q96D15	S117	Sugiyama	RCN3 UNQ239/PRO272	VsLAELRAWIAHTQQRHIRDsVsAAWDtyDtDRDGRVGWEE
Q96G46	S236	Sugiyama	DUS3L	QQLRKREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPR
Q99613	S865	Sugiyama	EIF3C EIF3S8	HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q9BY11	S346	SIGNOR	PACSIN1 KIAA1379	VALTNAtGAVEstsQAGDRGsVssyDRGQPYATEWsDDESG
Q9H7D7	S121	Sugiyama	WDR26 CDW2 MIP2 PRO0852	ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9NSB2	S178	Sugiyama	KRT84 KRTHB4	AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9Y2B0	S63	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI