PDHK1

All methods over the ±5 window, side by side.
PSPA
PSPA (TYR)
CDDM
MLP-attr
Normalized values from positional scanning peptide array
TYR version of PSPA with Y as phospho-acceptor
PSPA measures pT, so at flanking positions the pS row is a duplicate of the pT row. At position 0 the acceptor identity (pS, pT, pY) is genuine.
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Position-wise Probabilities (±5 window)
Log-Odds (±5 window)
Motifs stratified by phospho-acceptor (S / T / Y)
K-means sub-motif clusters
Signed attribution PSSM distilled from the CDDM discriminative MLP (in-silico saturation mutagenesis). Letters above 0 are enriched, below are depleted; this is not a probability distribution.
MLP-attribution PSSM (±5, signed)
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substrate_uniprot site source substrate_genes site_seq
O00141 S422 GPS6 SGK1 SGK PDsVLVTAsVKEAAEAFLGFsYAPPTDSFL___________
O00141 T256 GPS6 SGK1 SGK IVLTDFGLCKENIEHNsTtstFCGtPEyLAPEVLHKQPYDR
O15530 S241 GPS6 PDPK1 PDK1 ITDFGTAKVLSPESKQARANsFVGtAQYVSPELLTEKSACK
O15530 S25 GPS6 PDPK1 PDK1 TSQLyDAVPIQSSVVLCSCPsPSMVRTQtESstPPGIPGGS
O15530 S393 GPS6 PDPK1 PDK1 yGNyDNLLSQFGCMQVSSSSssHsLsASDTGLPQRSGsNIE
O15530 S396 GPS6 PDPK1 PDK1 yDNLLSQFGCMQVSSSSssHsLsASDTGLPQRSGsNIEQYI
O15530 S410 GPS6 PDPK1 PDK1 SSSssHsLsASDTGLPQRSGsNIEQYIHDLDSNSFELDLQF
O15530 T513 GPS6 PDPK1 PDK1 VLKGEIPWSQELRPEAKNFKtFFVHTPNRTYYLMDPSGNAH
O43707 Y878 Sugiyama ACTN4 DKNFITAEELRRELPPDQAEyCIARMAPyQGPDAVPGALDy
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60664 Y95 Sugiyama PLIN3 M6PRBP1 TIP47 VsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQPTE
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05106 T777 GPS6 ITGB3 GP3A EEERARAKWDtANNPLyKEAtstFtNItyRGt_________
P05106 T779 GPS6|iPTMNet ITGB3 GP3A ERARAKWDtANNPLyKEAtstFtNItyRGt___________
P07437 Y50 Sugiyama TUBB TUBB5 OK/SW-cl.56 IDPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEP
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S470 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08559 S232 iPTMNet|PSP PDHA1 PHE1A ALWKLPCIFICENNRYGMGtsVERAAAsTDYYKRGDFIPGL
P08559 S293 GPS6|ELM|iPTMNet|PSP PDHA1 PHE1A CRSGKGPILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsK
P08559 S300 GPS6|ELM|iPTMNet|PSP PDHA1 PHE1A ILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsKsDPIMLL
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P12814 Y859 Sugiyama ACTN1 DKNyITMDELRRELPPDQAEyCIARMAPYTGPDSVPGALDY
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13667 S379 Sugiyama PDIA4 ERP70 ERP72 QPEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGH
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23443 S427 GPS6 RPS6KB1 STK14A VFLGFtYVAPSVLESVKEKFsFEPKIRsPRRFIGsPRtPVs
P23443 T252 GPS6 RPS6KB1 STK14A VKLTDFGLCKEsIHDGTVtHtFCGTIEYMAPEILMRSGHNR
P23443 T390 iPTMNet RPS6KB1 STK14A KPLLQsEEDVsQFDSKFtRQtPVDsPDDstLsEsANQVFLG
P23443 T412 GPS6 RPS6KB1 STK14A VDsPDDstLsEsANQVFLGFtYVAPSVLESVKEKFsFEPKI
P26232 T657 Sugiyama CTNNA2 CAPR EDDsDFEQEDYDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P28066 Y8 Sugiyama PSMA5 _____________MFLTRsEyDRGVNtFsPEGRLFQVEyAI
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29803 S230 PSP PDHA2 PDHAL ALWKLPCVFICENNLYGMGTsTERAAASPDYYKRGNFIPGL
P29803 S291 PSP PDHA2 PDHAL CRSGKGPILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsK
P29803 S298 PSP PDHA2 PDHAL ILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsKRDPIIIL
P31749 S473 GPS6 AKT1 PKB RAC DQDDSMECVDSERRPHFPQFsysAsGtA_____________
P31749 T308 GPS6 AKT1 PKB RAC IKITDFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGR
P31751 T309 GPS6 AKT2 IKITDFGLCKEGISDGATMKtFCGtPEyLAPEVLEDNDyGR
P31943 Y266 Sugiyama HNRNPH1 HNRPH HNRPH1 yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P35221 T658 Sugiyama CTNNA1 LDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P36507 S226 GPS6 MAP2K2 MEK2 MKK2 PRKMK2 GEIKLCDFGVsGQLIDsMANsFVGtRSYMAPERLQGTHYSV
P48643 S270 Sugiyama CCT5 CCTE KIAA0098 ILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQ
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55060 S342 Sugiyama CSE1L CAS XPO2 ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF
P55795 Y266 Sugiyama HNRNPH2 FTP3 HNRPH2 YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q02156 T566 GPS6 PRKCE PKCE CKLADFGMCKEGILNGVTTTtFCGTPDyIAPEILQELEYGP
Q02750 S222 GPS6 MAP2K1 MEK1 PRKMK1 GEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGTHYSV
Q05513 T410 GPS6 PRKCZ PKC2 IKLTDYGMCKEGLGPGDTTstFCGTPNyIAPEILRGEEyGF
Q05655 T507 GPS6 PRKCD PKCD IKIADFGMCKENIFGEsRAstFCGtPDyIAPEILQGLKyTF
Q13153 T423 GPS6 PAK1 VKLTDFGFCAQITPEQSKRstMVGTPYWMAPEVVTRKAYGP
Q15118 S27 Sugiyama PDK1 PDHK1 LRGAALAGPGPGLRAAGFsRsFsSDSGSSPASERGVPGQVD
Q15118 S29 Sugiyama PDK1 PDHK1 GAALAGPGPGLRAAGFsRsFsSDSGSSPASERGVPGQVDFy
Q15118 S396 Sugiyama PDK1 PDHK1 YSLEGYGTDAVIYIKALsTDsIERLPVyNKAAWKHyNtNHE
Q15118 S424 Sugiyama PDK1 PDHK1 NKAAWKHyNtNHEADDWCVPsREPKDMTTFRSA________
Q15118 S67 Sugiyama PDK1 PDHK1 DFyARFSPSPLSMKQFLDFGsVNACEKTSFMFLRQELPVRL
Q15118 T413 Sugiyama PDK1 PDHK1 sTDsIERLPVyNKAAWKHyNtNHEADDWCVPsREPKDMTTF
Q15118 Y136 Sugiyama PDK1 PDHK1 QSLQELLDFKDKSAEDAKAIyDFTDTVIRIRNRHNDVIPTM
Q15118 Y368 Sugiyama PDK1 PDHK1 RAVPLAGFGYGLPISRLYAQyFQGDLKLYSLEGYGTDAVIY
Q15118 Y403 Sugiyama PDK1 PDHK1 TDAVIYIKALsTDsIERLPVyNKAAWKHyNtNHEADDWCVP
Q15118 Y411 Sugiyama PDK1 PDHK1 ALsTDsIERLPVyNKAAWKHyNtNHEADDWCVPsREPKDMT
Q15118 Y49 Sugiyama PDK1 PDHK1 sSDSGSSPASERGVPGQVDFyARFSPSPLSMKQFLDFGsVN
Q15418 S221 GPS6 RPS6KA1 MAPKAPK1A RSK1 IKLTDFGLSKEAIDHEKKAysFCGtVEYMAPEVVNRQGHSH
Q16512 T774 GPS6 PKN1 PAK1 PKN PRK1 PRKCL1 VKIADFGLCKEGMGyGDRtstFCGtPEFLAPEVLTDTSYTR
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16513 T816 GPS6 PKN2 PRK2 PRKCL2 VKIADFGLCKEGMGYGDRtstFCGtPEFLAPEVLTETSYTR
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q96BR1 T320 GPS6 SGK3 CISK SGKL VVLTDFGLCKEGIAISDTTTtFCGTPEYLAPEVIRKQPYDN
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q99683 T838 GPS6 MAP3K5 ASK1 MAPKKK5 MEKK5 LKISDFGtSKRLAGINPCTEtFTGtLQyMAPEIIDKGPRGY
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9UPQ0 S207 Sugiyama LIMCH1 KIAA1102 RsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVVLRGssD
Q9Y243 T305 GPS6 AKT3 PKBG IKITDFGLCKEGITDAATMKtFCGtPEyLAPEVLEDNDyGR
Q9Y639 Y220 Sugiyama NPTN SDFR1 SDR1 NMEYRINKPRAEDsGEyHCVyHFVsAPKANATIEVKAAPDI