PDK1

All methods over the ±5 window, side by side.

PSPA

CDDM

MLP-attr

Normalized values from positional scanning peptide array

PSPA measures pT, so at flanking positions the pS row is a duplicate of the pT row. At position 0 the acceptor identity (pS, pT, pY) is genuine.

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Position-wise Probabilities (±5 window)

Log-Odds (±5 window)

Motifs stratified by phospho-acceptor (S / T / Y)

K-means sub-motif clusters

Signed attribution PSSM distilled from the CDDM discriminative MLP (in-silico saturation mutagenesis). Letters above 0 are enriched, below are depleted; this is not a probability distribution.

MLP-attribution PSSM (±5, signed)

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substrate_uniprot	site	source	substrate_genes	site_seq
O00141	S422	SIGNOR\|ELM\|EPSD	SGK1 SGK	PDsVLVTAsVKEAAEAFLGFsYAPPTDSFL___________
O00141	T256	SIGNOR\|ELM\|EPSD\|PSP	SGK1 SGK	IVLTDFGLCKENIEHNsTtstFCGtPEyLAPEVLHKQPYDR
O14920	S181	EPSD	IKBKB IKKB	IHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQKyTV
O15530	S241	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PDPK1 PDK1	ITDFGTAKVLSPESKQARANsFVGtAQYVSPELLTEKSACK
O15530	S25	SIGNOR\|ELM\|EPSD\|PSP	PDPK1 PDK1	TSQLyDAVPIQSSVVLCSCPsPSMVRTQtESstPPGIPGGS
O15530	S393	SIGNOR\|ELM\|EPSD\|PSP	PDPK1 PDK1	yGNyDNLLSQFGCMQVSSSSssHsLsASDTGLPQRSGsNIE
O15530	S396	SIGNOR\|ELM\|EPSD\|PSP	PDPK1 PDK1	yDNLLSQFGCMQVSSSSssHsLsASDTGLPQRSGsNIEQYI
O15530	S410	SIGNOR\|ELM\|EPSD\|PSP	PDPK1 PDK1	SSSssHsLsASDTGLPQRSGsNIEQYIHDLDSNSFELDLQF
O15530	T33	iPTMNet\|EPSD	PDPK1 PDK1	PIQSSVVLCSCPsPSMVRTQtESstPPGIPGGSRQGPAMDG
O15530	T513	ELM\|iPTMNet\|EPSD\|PSP	PDPK1 PDK1	VLKGEIPWSQELRPEAKNFKtFFVHTPNRTYYLMDPSGNAH
O43865	S68	SIGNOR	AHCYL1 DCAL IRBIT XPVKONA	MQEFTKFPTKTGRRSLSRsIsQSsTDsySsAASYTDssDDE
O60331	S448	EPSD\|PSP	PIP5K1C KIAA0589	PSFYAERFFKFMSNTVFRKNsSLKSsPSKKGRGGALLAVKP
P00558	T243	SIGNOR\|PSP	PGK1 PGKA MIG10 OK/SW-cl.110	LINNMLDKVNEMIIGGGMAFtFLKVLNNMEIGTsLFDEEGA
P05106	T777	ELM\|EPSD	ITGB3 GP3A	EEERARAKWDtANNPLyKEAtstFtNItyRGt_________
P05106	T779	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	ITGB3 GP3A	ERARAKWDtANNPLyKEAtstFtNItyRGt___________
P05771	T500	SIGNOR	PRKCB PKCB PRKCB1	IKIADFGMCKENIWDGVttKtFCGtPDyIAPEIIAyQPYGK
P08559	S232	EPSD	PDHA1 PHE1A	ALWKLPCIFICENNRYGMGtsVERAAAsTDYYKRGDFIPGL
P08559	S293	EPSD\|PSP	PDHA1 PHE1A	CRSGKGPILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsK
P08559	S300	EPSD	PDHA1 PHE1A	ILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsKsDPIMLL
P10636	S46	EPSD	MAPT MAPTL MTBT1 TAU	QGGytMHQDQEGDtDAGLKEsPLQtPTEDGsEEPGsETSDA
P10636	S515	EPSD	MAPT MAPTL MTBT1 TAU	APKtPPsSGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtP
P10636	S516	EPSD	MAPT MAPTL MTBT1 TAU	PKtPPsSGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtPP
P10636	S519	EPSD	MAPT MAPTL MTBT1 TAU	PPsSGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtPPTRE
P10636	S552	EPSD	MAPT MAPTL MTBT1 TAU	LPtPPTREPKKVAVVRtPPKsPssAKSRLQTAPVPMPDLKN
P10636	S739	EPSD	MAPT MAPTL MTBT1 TAU	DtsPRHLsNVsstGsIDMVDsPQLAtLADEVSASLAKQGL_
P10636	T470	EPSD	MAPT MAPTL MTBT1 TAU	GSSGAKEMKLKGADGKTKIAtPRGAAPPGQKGQANATRIPA
P10636	T492	EPSD	MAPT MAPTL MTBT1 TAU	RGAAPPGQKGQANATRIPAKtPPAPKtPPsSGEPPKsGDRs
P10636	T498	EPSD	MAPT MAPTL MTBT1 TAU	GQKGQANATRIPAKtPPAPKtPPsSGEPPKsGDRsGyssPG
P10636	T50	EPSD	MAPT MAPTL MTBT1 TAU	tMHQDQEGDtDAGLKEsPLQtPTEDGsEEPGsETSDAKstP
P10636	T522	EPSD	MAPT MAPTL MTBT1 TAU	SGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtPPTREPKK
P10636	T529	EPSD	MAPT MAPTL MTBT1 TAU	GDRsGyssPGsPGtPGsRsRtPsLPtPPTREPKKVAVVRtP
P10636	T534	EPSD	MAPT MAPTL MTBT1 TAU	yssPGsPGtPGsRsRtPsLPtPPTREPKKVAVVRtPPKsPs
P17600	S551	EPSD	SYN1	RQSRPVAGGPGAPPAARPPAsPsPQRQAGPPQATRQTsVSG
P17612	T198	EPSD\|PSP	PRKACA PKACA	QGYIQVTDFGFAKRVKGRtWtLCGtPEYLAPEIILsKGYNK
P23443	S394	PSP	RPS6KB1 STK14A	QsEEDVsQFDSKFtRQtPVDsPDDstLsEsANQVFLGFtYV
P23443	S427	ELM\|EPSD	RPS6KB1 STK14A	VFLGFtYVAPSVLESVKEKFsFEPKIRsPRRFIGsPRtPVs
P23443	T252	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	RPS6KB1 STK14A	VKLTDFGLCKEsIHDGTVtHtFCGTIEYMAPEILMRSGHNR
P23443	T390	EPSD	RPS6KB1 STK14A	KPLLQsEEDVsQFDSKFtRQtPVDsPDDstLsEsANQVFLG
P23443	T412	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	RPS6KB1 STK14A	VDsPDDstLsEsANQVFLGFtYVAPSVLESVKEKFsFEPKI
P31749	S473	SIGNOR\|ELM\|EPSD\|PSP	AKT1 PKB RAC	DQDDSMECVDSERRPHFPQFsysAsGtA_____________
P31749	T308	SIGNOR\|ELM\|EPSD\|PSP	AKT1 PKB RAC	IKITDFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGR
P31751	S474	SIGNOR\|EPSD	AKT2	DRyDsLGLLELDQRTHFPQFsysAsIRE_____________
P31751	T309	SIGNOR\|ELM\|EPSD\|PSP	AKT2	IKITDFGLCKEGISDGATMKtFCGtPEyLAPEVLEDNDyGR
P31946	S60	ELM	YWHAB	NEERNLLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQM
P36507	S226	SIGNOR\|ELM\|EPSD\|PSP	MAP2K2 MEK2 MKK2 PRKMK2	GEIKLCDFGVsGQLIDsMANsFVGtRSYMAPERLQGTHYSV
P51812	S227	SIGNOR	RPS6KA3 ISPK1 MAPKAPK1B RSK2	IKLTDFGLSKESIDHEKKAysFCGtVEYMAPEVVNRRGHTQ
Q02156	T566	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PRKCE PKCE	CKLADFGMCKEGILNGVTTTtFCGTPDyIAPEILQELEYGP
Q02750	S222	SIGNOR\|ELM\|EPSD\|PSP	MAP2K1 MEK1 PRKMK1	GEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGTHYSV
Q04917	S59	ELM	YWHAH YWHA1	NEDRNLLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKL
Q05513	T410	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PRKCZ PKC2	IKLTDYGMCKEGLGPGDTTstFCGTPNyIAPEILRGEEyGF
Q05655	T507	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PRKCD PKCD	IKIADFGMCKENIFGEsRAstFCGtPDyIAPEILQGLKyTF
Q13153	T423	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PAK1	VKLTDFGFCAQITPEQSKRstMVGTPYWMAPEVVTRKAYGP
Q15118	S25	EPSD	PDK1 PDHK1	RLLRGAALAGPGPGLRAAGFsRsFsSDSGSSPASERGVPGQ
Q15118	S393	EPSD	PDK1 PDHK1	LKLYSLEGYGTDAVIYIKALsTDsIERLPVyNKAAWKHyNt
Q15118	S396	EPSD	PDK1 PDHK1	YSLEGYGTDAVIYIKALsTDsIERLPVyNKAAWKHyNtNHE
Q15349	S218	EPSD	RPS6KA2 MAPKAPK1C RSK3	IKITDFGLSKEAIDHDKRAYsFCGtIEYMAPEVVNRRGHTQ
Q15418	S221	SIGNOR\|ELM\|EPSD\|PSP	RPS6KA1 MAPKAPK1A RSK1	IKLTDFGLSKEAIDHEKKAysFCGtVEYMAPEVVNRQGHSH
Q16512	S773	EPSD\|PSP	PKN1 PAK1 PKN PRK1 PRKCL1	YVKIADFGLCKEGMGyGDRtstFCGtPEFLAPEVLTDTSYT
Q16512	T774	SIGNOR\|ELM\|EPSD\|PSP	PKN1 PAK1 PKN PRK1 PRKCL1	VKIADFGLCKEGMGyGDRtstFCGtPEFLAPEVLTDTSYTR
Q16513	T816	SIGNOR\|ELM\|EPSD\|PSP	PKN2 PRK2 PRKCL2	VKIADFGLCKEGMGYGDRtstFCGtPEFLAPEVLTETSYTR
Q16513	T951	EPSD	PKN2 PRK2 PRKCL2	PPFIPTIRGREDVSNFDDEFtsEAPILtPPREPRILsEEEQ
Q96BR1	S486	SIGNOR\|iPTMNet\|EPSD	SGK3 CISK SGKL	SDYSIVNASVLEADDAFVGFsYAPPSEDLFL__________
Q96BR1	T320	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	SGK3 CISK SGKL	VVLTDFGLCKEGIAISDTTTtFCGTPEYLAPEVIRKQPYDN
Q96PN8	T168	SIGNOR	TSSK3 SPOGA3 STK22C	KLTDFGFAKVLPKSHRELsQtFCGSTAYAAPEVLQGIPHDS
Q99683	S966	EPSD\|PSP	MAP3K5 ASK1 MAPKKK5 MEKK5	KTQPKLSALSAGsNEYLRsIsLPVPVLVEDtssssEYGsVs
Q99683	T838	ELM\|EPSD	MAP3K5 ASK1 MAPKKK5 MEKK5	LKISDFGtSKRLAGINPCTEtFTGtLQyMAPEIIDKGPRGY
Q99814	T324	EPSD\|PSP	EPAS1 BHLHE73 HIF2A MOP2 PASD2	SGQYRMLAKHGGYVWLETQGtVIYNPRNLQPQCIMCVNYVL
Q9HBY8	T193	SIGNOR	SGK2	VVLTDFGLCKEGVEPEDTTStFCGTPEYLAPEVLRKEPYDR
Q9UBS0	S370	SIGNOR\|EPSD	RPS6KB2 STK14B	QSEEDVSQFDTRFTRQTPVDsPDDTALSESANQAFLGFtYV
Q9UBS0	T228	SIGNOR\|EPSD	RPS6KB2 STK14B	IKLTDFGLCKESIHEGAVTHtFCGTIEYMAPEILVRSGHNR
Q9UBS0	T388	SIGNOR\|EPSD	RPS6KB2 STK14B	VDsPDDTALSESANQAFLGFtYVAPSVLDSIKEGFsFQPKL
Q9Y243	S120	EPSD	AKT3 PKBG	EAIQAVADRLQRQEEERMNCsPtsQIDNIGEEEMDAsTtHH
Q9Y243	T305	SIGNOR\|ELM\|EPSD\|PSP	AKT3 PKBG	IKITDFGLCKEGITDAATMKtFCGtPEyLAPEVLEDNDyGR