TTK

All methods over the ±5 window, side by side.

PSPA

CDDM

MLP-attr

Normalized values from positional scanning peptide array

PSPA measures pT, so at flanking positions the pS row is a duplicate of the pT row. At position 0 the acceptor identity (pS, pT, pY) is genuine.

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Position-wise Probabilities (±5 window)

Log-Odds (±5 window)

Motifs stratified by phospho-acceptor (S / T / Y)

K-means sub-motif clusters

Signed attribution PSSM distilled from the CDDM discriminative MLP (in-silico saturation mutagenesis). Letters above 0 are enriched, below are depleted; this is not a probability distribution.

MLP-attribution PSSM (±5, signed)

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substrate_uniprot	site	source	substrate_genes	site_seq
O14950	T160	Sugiyama	MYL12B MRLC2 MYLC2B	DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
O14979	T165	Sugiyama	HNRNPDL HNRPDL JKTBP	QDDGKMFIGGLSWDTsKKDLtEyLSRFGEVVDCtIKTDPVT
O60566	S1043	EPSD\|PSP	BUB1B BUBR1 MAD3L SSK1	FDTTFQSHLNKALWKVGKLtsPGALLFQ_____________
O60566	S435	EPSD\|PSP	BUB1B BUBR1 MAD3L SSK1	IRAEVFRKKLKEQREAELLtsAEKRAEMQKQIEEMEKKLKE
O60566	S543	EPSD\|PSP	BUB1B BUBR1 MAD3L SSK1	GPsVPFSIFDEFLLSEKKNKsPPADPPRVLAQRRPLAVLKt
O60566	S670	EPSD\|PSP	BUB1B BUBR1 MAD3L SSK1	EDQQTACGtIysQtLsIKKLsPIIEDsREAtHSsGFsGSSA
O96017	T68	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CHEK2 CDS1 CHK2 RAD53	NSsQSSHSSSGTLSsLETVStQELYsIPEDQEPEDQEPEEP
P00519	T735	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	ABL1 ABL JTK7	RsCsAsCVPHGAKDTEWRSVtLPRDLQStGRQFDSstFGGH
P04637	T18	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	TP53 P53	___MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQ
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P06733	T19	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	__MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGA
P06733	T26	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P07900	T115	EPSD\|PSP	HSP90AA1 HSP90A HSPC1 HSPCA	GIGMTKADLINNLGtIAKSGtKAFMEALQAGADISMIGQFG
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P19105	T159	Sugiyama	MYL12A MLCB MRLC3 RLC	DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27816	S928	SIGNOR\|PSP	MAP4	PTSAKPssttPRLSRLAtNtsAPDLKNVRsKVGstENIKHQ
P27816	T927	SIGNOR\|PSP	MAP4	KPTSAKPssttPRLSRLAtNtsAPDLKNVRsKVGstENIKH
P30305	S169	ELM	CDC25B CDC25HU2	FQsMPVRLLGHsPVLRNItNsQAPDGRRKsEAGSGAAssSG
P30305	S323	ELM	CDC25B CDC25HU2	KEEEKDLVMYSKCQRLFRsPsMPCSVIRPILKRLERPQDRD
P33981	S15	EPSD\|PSP\|Sugiyama	TTK MPS1 MPS1L1	______MESEDLsGRELtIDsIMNKVRDIKNKFKNEDLtDE
P33981	S214	SIGNOR	TTK MPS1 MPS1L1	LLSEEEKKNLSASTVLtAQEsFSGSLGHLQNRNNSCDSRGQ
P33981	S321	SIGNOR\|PSP\|Sugiyama	TTK MPS1 MPS1L1	TSRSECRDLVVPGSKPsGNDsCELRNLKSVQNsHFKEPLVS
P33981	S362	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	DEKsSELIITDSITLKNKtEssLLAKLEEtKEyQEPEVPEs
P33981	S363	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	EKsSELIITDSITLKNKtEssLLAKLEEtKEyQEPEVPEsN
P33981	S37	SIGNOR\|EPSD\|PSP\|Sugiyama	TTK MPS1 MPS1L1	MNKVRDIKNKFKNEDLtDELsLNKIsADttDNsGtVNQIMM
P33981	S436	EPSD\|PSP	TTK MPS1 MPS1L1	VNTEQKHTTFEQPVFSVSKQsPPISTSKWFDPKSICKtPss
P33981	S49	PSP	TTK MPS1 MPS1L1	NEDLtDELsLNKIsADttDNsGtVNQIMMMANNPEDWLSLL
P33981	S582	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	NQtLDSYRNEIAYLNKLQQHsDKIIRLYDYEItDQYIYMVM
P33981	S677	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	DGMLKLIDFGIANQMQPDttsVVKDSQVGtVNYMPPEAIKD
P33981	S7	PSP	TTK MPS1 MPS1L1	______________MESEDLsGRELtIDsIMNKVRDIKNKF
P33981	S742	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	CILYYMTYGKTPFQQIINQIsKLHAIIDPNHEIEFPDIPEK
P33981	S80	EPSD\|PSP\|Sugiyama	TTK MPS1 MPS1L1	NNPEDWLSLLLKLEKNSVPLsDALLNKLIGRYSQAIEALPP
P33981	S821	EPSD\|PSP	TTK MPS1 MPS1L1	MAKGttEEMKyVLGQLVGLNsPNsILKAAKTLyEHYsGGES
P33981	S824	EPSD\|PSP	TTK MPS1 MPS1L1	GttEEMKyVLGQLVGLNsPNsILKAAKTLyEHYsGGESHNs
P33981	S844	Sugiyama	TTK MPS1 MPS1L1	sILKAAKTLyEHYsGGESHNssssKtFEKKRGKK_______
P33981	S845	EPSD\|PSP	TTK MPS1 MPS1L1	ILKAAKTLyEHYsGGESHNssssKtFEKKRGKK________
P33981	S847	EPSD\|PSP	TTK MPS1 MPS1L1	KAAKTLyEHYsGGESHNssssKtFEKKRGKK__________
P33981	T12	SIGNOR\|EPSD\|PSP\|Sugiyama	TTK MPS1 MPS1L1	_________MESEDLsGRELtIDsIMNKVRDIKNKFKNEDL
P33981	T288	EPSD\|PSP	TTK MPS1 MPS1L1	SCPFGRVPVNLLNsPDCDVKtDDsVVPCFMKRQTSRSECRD
P33981	T33	SIGNOR\|EPSD\|PSP\|Sugiyama	TTK MPS1 MPS1L1	IDsIMNKVRDIKNKFKNEDLtDELsLNKIsADttDNsGtVN
P33981	T360	EPSD\|PSP	TTK MPS1 MPS1L1	VSDEKsSELIITDSITLKNKtEssLLAKLEEtKEyQEPEVP
P33981	T371	SIGNOR\|PSP	TTK MPS1 MPS1L1	TDSITLKNKtEssLLAKLEEtKEyQEPEVPEsNQKQWQSKR
P33981	T45	PSP	TTK MPS1 MPS1L1	NKFKNEDLtDELsLNKIsADttDNsGtVNQIMMMANNPEDW
P33981	T46	PSP	TTK MPS1 MPS1L1	KFKNEDLtDELsLNKIsADttDNsGtVNQIMMMANNPEDWL
P33981	T564	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	NEKKQIYAIKYVNLEEADNQtLDSYRNEIAYLNKLQQHsDK
P33981	T675	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	IVDGMLKLIDFGIANQMQPDttsVVKDSQVGtVNYMPPEAI
P33981	T676	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	TTK MPS1 MPS1L1	VDGMLKLIDFGIANQMQPDttsVVKDSQVGtVNYMPPEAIK
P33981	T686	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	TTK MPS1 MPS1L1	GIANQMQPDttsVVKDSQVGtVNYMPPEAIKDMSSSRENGK
P33981	T795	EPSD\|PSP	TTK MPS1 MPS1L1	DPKQRISIPELLAHPYVQIQtHPVNQMAKGttEEMKyVLGQ
P33981	T805	EPSD\|PSP	TTK MPS1 MPS1L1	LLAHPYVQIQtHPVNQMAKGttEEMKyVLGQLVGLNsPNsI
P33981	T806	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	LAHPYVQIQtHPVNQMAKGttEEMKyVLGQLVGLNsPNsIL
P33981	T849	EPSD\|PSP	TTK MPS1 MPS1L1	AKTLyEHYsGGESHNssssKtFEKKRGKK____________
P33981	Y811	EPSD\|PSP	TTK MPS1 MPS1L1	VQIQtHPVNQMAKGttEEMKyVLGQLVGLNsPNsILKAAKT
P35221	S641	Sugiyama	CTNNA1	GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P38646	S65	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	HSPA9 GRP75 HSPA9B mt-HSP70	DyASEAIKGAVVGIDLGtTNsCVAVMEGKQAKVLENAEGAR
P38646	T62	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	HSPA9 GRP75 HSPA9B mt-HSP70	SRRDyASEAIKGAVVGIDLGtTNsCVAVMEGKQAKVLENAE
P54132	S1290	EPSD\|PSP	BLM RECQ2 RECQL3	KLEKYGAEVIsVLQKYSEWTsPAEDssPGIsLsSSRGPGRs
P54132	S1296	EPSD\|PSP	BLM RECQ2 RECQL3	AEVIsVLQKYSEWTsPAEDssPGIsLsSSRGPGRsAAEELD
P54132	S144	EPSD\|PSP	BLM RECQ2 RECQL3	NtPtVKKSRDTALKKLEFsssPDsLstINDWDDMDDFDTSE
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62424	T84	Sugiyama	RPL7A SURF-3 SURF3	QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62899	T26	Sugiyama	RPL31	KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P67809	T108	Sugiyama	YBX1 NSEP1 YB1	QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P84098	T29	Sugiyama	RPL19	RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q14247	T328	Sugiyama	CTTN EMS1	GKyGVQKDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKts
Q15637	S82	Sugiyama	SF1 ZFM1 ZNF162	TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q53HL2	S238	GPS6\|EPSD\|PSP	CDCA8 PESCRG3	GsPLADsKEIFLtVPVGGGEsLRLLAsDLQRHsIAQLDPEA
Q53HL2	T169	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDCA8 PESCRG3	KKRTQsIQGKGKGKRSsRANtVTPAVGRLEVSMVKPTPGLT
Q53HL2	T230	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDCA8 PESCRG3	RIyNIsGNGsPLADsKEIFLtVPVGGGEsLRLLAsDLQRHs
Q53HL2	T88	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDCA8 PESCRG3	MNWLDYFALGGNKQALEEAAtADLDItEINKLTAEAIQtPL
Q53HL2	T94	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDCA8 PESCRG3	FALGGNKQALEEAAtADLDItEINKLTAEAIQtPLKsAKTR
Q6IBW4	S492	PSP	NCAPH2 CAPH2	RRNVELFIATSQKFVQETELsQRIRDWEDtVQPLLQEQEQH
Q96B36	T233	Sugiyama	AKT1S1 PRAS40	PDLDRIAAsMRALVLREAEDtQVFGDLPRPRLNtsDFQKLK
Q96E14	S112	EPSD\|PSP	RMI2 C16orf75	GRPCLVPGKYVMVMGVVQACsPEPCLQAVKMTDLSDNPIHE
Q96PE2	T1007	EPSD\|PSP	ARHGEF17 KIAA0337 TEM4	PIGFPTRAHPTLQAPsLEDVtKQYMLNLHSGEVPAPVPVDM
Q96PE2	T751	EPSD\|PSP	ARHGEF17 KIAA0337 TEM4	YRsLsDPIPQRHRAATSEEPtGFSVDSNLLGsLsPKTGLPA
Q96PE2	T944	EPSD\|PSP	ARHGEF17 KIAA0337 TEM4	KRPARSSHQELRRDEGSQDQtGsLSRARPSSRHVRHAsVPA
Q9BQ16	T118	Sugiyama	SPOCK3 TICN3 UNQ409/PRO771	HKVCIAQDSQTAVCISHRRLtHRMKEAGVDHRQWRGPILST
Q9H444	T103	Sugiyama	CHMP4B C20orf178 SHAX1	DGtLstIEFQREALENANtNtEVLKNMGYAAKAMKAAHDNM
Q9Y2T7	T143	Sugiyama	YBX2 CSDA3 MSY2	QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y5T5	S415	SIGNOR\|EPSD\|PSP	USP16 MSTP039	GKKSVNDKNLKKTVEDEDQDsEEEKDNDsYIKERSDIPSGT
Q9Y5T5	S552	EPSD\|PSP	USP16 MSTP039	TEEVDMKNINMDNDLEVLtssPtRNLNGAYLTEGSNGEVDI
Q9Y5T5	T554	SIGNOR\|EPSD\|PSP	USP16 MSTP039	EVDMKNINMDNDLEVLtssPtRNLNGAYLTEGSNGEVDISN
Q9Y6D9	S22	EPSD\|PSP	MAD1L1 MAD1 TXBP181	EDLGENtMVLSTLRsLNNFIsQRVEGGsGLDISTSAPGSLQ
Q9Y6D9	S598	EPSD\|PSP	MAD1L1 MAD1 TXBP181	MERGGTVPADLEAAAASLPSsKEVAELKKQVEsAELKNQRL
Q9Y6D9	S610	EPSD\|PSP	MAD1L1 MAD1 TXBP181	AAAASLPSsKEVAELKKQVEsAELKNQRLKEVFQtKIQEFR
Q9Y6D9	S62	EPSD\|PSP	MAD1L1 MAD1 TXBP181	QMQYQQSMQLEERAEQIRSKsHLIQVEREKMQMELsHKRAR
Q9Y6D9	T323	EPSD\|PSP	MAD1L1 MAD1 TXBP181	LELENERLLAKLQSWERLDQtMGLSIRTPEDLSRFVVELQQ
Q9Y6D9	T624	EPSD\|PSP	MAD1L1 MAD1 TXBP181	LKKQVEsAELKNQRLKEVFQtKIQEFRKACyTLTGYQIDIT
Q9Y6D9	T716	EPSD\|PSP	MAD1L1 MAD1 TXBP181	RQDsIPAFLSSLtLELFSRQtVA__________________
Q9Y6D9	T8	EPSD\|PSP	MAD1L1 MAD1 TXBP181	_____________MEDLGENtMVLSTLRsLNNFIsQRVEGG
Q9Y6R1	S12	PSP	SLC4A4 NBC NBC1 NBCE1	_________MEDEAVLDRGAsFLKHVCDEEEVEGHHTIYIG